PMID- 29341602
OWN - NLM
STAT- MEDLINE
DCOM- 20190917
LR  - 20191008
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 52
IP  - 4
DP  - 2018 Feb 20
TI  - Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and 
      2,2-Bis(4-chlorophenyl)-1,1-dichloroethene in 7- and 9-Year-Old Children and 
      Their Mothers in the Center for the Health Assessment of Mothers and Children of 
      Salinas Cohort.
PG  - 2287-2294
LID - 10.1021/acs.est.7b05460 [doi]
AB  - We report longitudinal serum concentrations of select persistent organic 
      pollutants (POPs) in children at ages 7 and 9 years and in their mothers 
      prenatally and again when the children were 9 years old. The participating 
      families were enrolled in the Center for the Health Assessment of Mothers and 
      Children of Salinas (CHAMACOS), a longitudinal birth cohort study of low-income 
      Hispanic families residing in the Salinas Valley, California. We observed 
      decreasing concentrations in the mothers with year of serum collection (2009 vs 
      2011) for six out of seven polybrominated diphenyl ether (PBDE) congeners and for 
      2,2',4,4',5-pentachlorobiphenyl (CB-99; p < 0.05). The 9-year-old children had 
      similarly decreasing serum concentrations of all seven PBDE congeners, CB-99, and 
      2,2',3,4,4',5'- and 2,3,3',4,4',6-hexachlorobiphenyl (CB-138/158) with year of 
      serum collection (2009 vs 2011; p < 0.05). In mixed effect models accounting for 
      weight gain as the children aged from 7 to 9 years, we observed an annual 
      decrease (-8.3% to -13.4%) in tri- to hexaBDE concentrations (p < 0.001), except 
      for 2,2',3,4,4'-tetrabromodiphenyl ether (BDE-85) and 
      2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153). The concentrations of these 
      congeners were not associated with time of serum collection and instead showed an 
      -0.9% to -2.6% decrease per kilogram of weight gain during the study period (p < 
      0.05). In the case of tetra- to heptachlorobiphenyls, we observed -0.5% to -0.7% 
      decrease in serum concentration per kilogram of weight gain (p < 0.05) and -3.0% 
      to -3.7% decrease in serum concentration per year of aging (p < 0.05), except for 
      2,3',4,4',5-pentachlorobiphenyl (CB-118) and 2,2',4,4',5,5'-hexachlorobiphenyl 
      (CB-153), which were not associated with time of serum draw. 
      2,2-Bis(4-chlorophenyl)-1,1-dichloroethene (p,p'-DDE) decreased -2.4%/kg of 
      weight gain between the two sampling points (p < 0.001). These findings suggest 
      that as children grow, dilution in a larger body size plays an important role in 
      explaining reductions in body burden in the case of traditional POPs such as PCBs 
      and p,p'-DDE. By contrast, in the case of PBDEs, reductions are likely explained 
      by reduction in exposure, as illustrated by decreased concentrations in more 
      recent years, possibly amplified by presumed shorter biological half-life than 
      other POPs.
FAU - Sjodin, Andreas
AU  - Sjodin A
AUID- ORCID: 0000-0002-0997-5758
AD  - Division of Laboratory Sciences, National Center for Environmental Health, 
      Centers for Disease Control and Prevention , 4770 Buford Highway, Atlanta, 
      Georgia 30341, United States.
FAU - Jones, Richard S
AU  - Jones RS
AD  - Division of Laboratory Sciences, National Center for Environmental Health, 
      Centers for Disease Control and Prevention , 4770 Buford Highway, Atlanta, 
      Georgia 30341, United States.
FAU - Gunier, Robert B
AU  - Gunier RB
AUID- ORCID: 0000-0001-5485-9919
AD  - Center for Environmental Research and Children's Health, School of Public Health, 
      University of California , 1995 University Avenue, Berkeley, California 94720, 
      United States.
FAU - Wong, Lee-Yang
AU  - Wong LY
AD  - Division of Laboratory Sciences, National Center for Environmental Health, 
      Centers for Disease Control and Prevention , 4770 Buford Highway, Atlanta, 
      Georgia 30341, United States.
FAU - Holland, Nina
AU  - Holland N
AD  - Center for Environmental Research and Children's Health, School of Public Health, 
      University of California , 1995 University Avenue, Berkeley, California 94720, 
      United States.
FAU - Eskenazi, Brenda
AU  - Eskenazi B
AD  - Center for Environmental Research and Children's Health, School of Public Health, 
      University of California , 1995 University Avenue, Berkeley, California 94720, 
      United States.
FAU - Bradman, Asa
AU  - Bradman A
AD  - Center for Environmental Research and Children's Health, School of Public Health, 
      University of California , 1995 University Avenue, Berkeley, California 94720, 
      United States.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
GR  - P01 ES009605/ES/NIEHS NIH HHS/United States
GR  - R01 ES015572/ES/NIEHS NIH HHS/United States
GR  - R01 OH007400/OH/NIOSH CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180131
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Dichloroethylenes)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 21SK105J9D (vinylidene chloride)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - California
MH  - Child
MH  - Cohort Studies
MH  - Dichloroethylenes
MH  - *Environmental Pollutants
MH  - Female
MH  - Halogenated Diphenyl Ethers
MH  - Humans
MH  - Maternal Exposure
MH  - Mothers
MH  - *Polybrominated Biphenyls
MH  - *Polychlorinated Biphenyls
PMC - PMC5894514
MID - NIHMS953763
EDAT- 2018/01/18 06:00
MHDA- 2019/09/19 06:00
PMCR- 2019/02/20
CRDT- 2018/01/18 06:00
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2018/01/18 06:00 [entrez]
PHST- 2019/02/20 00:00 [pmc-release]
AID - 10.1021/acs.est.7b05460 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2018 Feb 20;52(4):2287-2294. doi: 10.1021/acs.est.7b05460. 
      Epub 2018 Jan 31.