PMID- 29344438
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 9
IP  - 11
DP  - 2017 Nov 13
TI  - New Therapeutic Approaches in Obesity and Metabolic Syndrome Associated with 
      Polycystic Ovary Syndrome.
PG  - e1844
LID - 10.7759/cureus.1844 [doi]
LID - e1844
AB  - Polycystic ovary syndrome (PCOS) is a pathophysiological disorder affecting 
      reproductive and metabolic indices. PCOS is commonly associated with a high 
      prevalence of insulin resistance and obesity; this association carries an 
      increased risk of developing metabolic syndrome, type 2 diabetes mellitus (T2DM), 
      and cardiovascular disease. Guidelines recommend lifestyle modification, 
      metformin, hormonal contraceptives (HCs), and bariatric surgery as the main 
      treatment options in obese patients with PCOS. Studies are being conducted to 
      test the efficacy of existing treatment options as well as to discover new 
      therapies. This review focuses on the most recent advances in this regard and 
      highlights new hypotheses and emerging studies to give a picture of the latest 
      therapeutic trends in the treatment of obese patients with PCOS. In this respect, 
      much attention is given to the role of inositols, the mediators of insulin 
      action. A deficiency of d-chiro-inositol containing inositol-phospho-glycans may 
      be the basis of insulin resistance frequently seen in PCOS patients. Moreover, 
      evidence suggests the use of statins in obese women with PCOS, but guidelines 
      call for further research. Adiponectin, quercetin, vitamin D, and anti-obesity 
      drugs have also been studied and seem to have a useful role in the treatment of 
      obesity and metabolic syndrome in PCOS. Many trials have been conducted on the 
      use of non-pharmacological therapies. Therapies including resveratrol, 
      acupuncture, and berberine have favorable effects in overweight PCOS patients. 
      However, more research is needed to reveal the clinical complexity of PCOS and 
      develop more effective treatment options.
FAU - Saleem, Fatima
AU  - Saleem F
AD  - Internal medicine, King Edward Medical University Lahore, Pakistan.
FAU - Rizvi, Syed W
AU  - Rizvi SW
AD  - R Endocrinology, New Jersey, Asst. Professor, Internal Medicine and 
      Endocrinology, Umdnj.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171113
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC5766352
OTO - NOTNLM
OT  - hyperandrogenism
OT  - inositols
OT  - insulin resistance
OT  - metabolic syndrome
OT  - metformin
OT  - obesity
OT  - pcos
OT  - polycystic ovary syndrome
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/01/19 06:00
MHDA- 2018/01/19 06:01
PMCR- 2017/11/13
CRDT- 2018/01/19 06:00
PHST- 2018/01/19 06:00 [entrez]
PHST- 2018/01/19 06:00 [pubmed]
PHST- 2018/01/19 06:01 [medline]
PHST- 2017/11/13 00:00 [pmc-release]
AID - 10.7759/cureus.1844 [doi]
PST - epublish
SO  - Cureus. 2017 Nov 13;9(11):e1844. doi: 10.7759/cureus.1844.