PMID- 29345001
OWN - NLM
STAT- MEDLINE
DCOM- 20190918
LR  - 20190918
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 107
IP  - 5
DP  - 2018 May
TI  - Wheat oral immunotherapy was moderately successful but was associated with very 
      frequent adverse events in children aged 6-18 years.
PG  - 861-870
LID - 10.1111/apa.14226 [doi]
AB  - AIM: This study investigated oral immunotherapy (OIT) for children aged 6-18 
      years with wheat allergies. METHODS: Well-cooked wheat spaghetti was given to 100 
      children with wheat allergies every day for 17 weeks, increasing from 0.3 to 2000 
      mg of wheat protein, followed by three- and nine-month maintenance phases. Blood 
      samples were taken before therapy and at follow-up visits. The study was carried 
      out in 2009-2015 in four Finnish paediatric allergology units. RESULTS: The 
      children (67% male) had a mean age of 11.6 years (range 6.1-18.6), and 57 were 
      using wheat daily 16 months after the initiation of therapy. Allergic symptoms 
      occurred in 94/100 children: mild in 34, moderate in 36 and severe in 24. 
      Specific immunoglobulin E (IgE) for omega-5-gliadin was significantly higher in 
      patients who did not reach the target dose and were related to the intensity of 
      reactions. CONCLUSION: The majority (57%) of children with wheat allergies could 
      use wheat in their daily diet 16 months after the initiation of OIT, but 94/100 
      had adverse reactions and 60 were moderate or severe. Specific IgE to omega-5-gliadin 
      may provide a biomarker for how much wheat can be tolerated and the intensity of 
      the reactions to immunotherapy.
CI  - (c)2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Kulmala, Petri
AU  - Kulmala P
AUID- ORCID: 0000-0003-2895-8563
AD  - PEDEGO Research Unit, Medical Research Center (MRC) Oulu, University of Oulu and 
      Oulu University Hospital, Oulu, Finland.
AD  - Biomedicine Research Unit, Clinical Microbiology and Immunology, University of 
      Oulu, Oulu, Finland.
FAU - Pelkonen, Anna S
AU  - Pelkonen AS
AD  - Department of Allergy, Skin and Allergy Hospital, Helsinki University Hospital, 
      Helsinki, Finland.
AD  - University of Helsinki, Helsinki, Finland.
FAU - Kuitunen, Mikael
AU  - Kuitunen M
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Paassilta, Marita
AU  - Paassilta M
AD  - Allergy Center, Tampere University Hospital, Tampere, Finland.
FAU - Remes, Sami
AU  - Remes S
AD  - Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
FAU - Schultz, Rudiger
AU  - Schultz R
AD  - Allergy Center, Tampere University Hospital, Tampere, Finland.
AD  - Pihlajalinna Medical Center, Tampere, Finland.
FAU - Dunder, Teija
AU  - Dunder T
AD  - PEDEGO Research Unit, Medical Research Center (MRC) Oulu, University of Oulu and 
      Oulu University Hospital, Oulu, Finland.
FAU - Turunen, Sami
AU  - Turunen S
AD  - PEDEGO Research Unit, Medical Research Center (MRC) Oulu, University of Oulu and 
      Oulu University Hospital, Oulu, Finland.
FAU - Makela, Mika J
AU  - Makela MJ
AD  - Department of Allergy, Skin and Allergy Hospital, Helsinki University Hospital, 
      Helsinki, Finland.
AD  - University of Helsinki, Helsinki, Finland.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180206
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunotherapy/adverse effects/methods/*statistics & numerical data
MH  - Male
MH  - Prospective Studies
MH  - Wheat Hypersensitivity/blood/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Children
OT  - Desensitisation
OT  - Food allergy
OT  - Oral immunotherapy
OT  - Wheat
EDAT- 2018/01/19 06:00
MHDA- 2019/09/19 06:00
CRDT- 2018/01/19 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2017/12/07 00:00 [revised]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/01/19 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2018/01/19 06:00 [entrez]
AID - 10.1111/apa.14226 [doi]
PST - ppublish
SO  - Acta Paediatr. 2018 May;107(5):861-870. doi: 10.1111/apa.14226. Epub 2018 Feb 6.