PMID- 29345393
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20220210
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 21
IP  - 5
DP  - 2018 Jul
TI  - The Protective Effect of Spinal Cord Stimulation Postconditioning Against Spinal 
      Cord Ischemia/Reperfusion Injury in Rabbits.
PG  - 448-456
LID - 10.1111/ner.12751 [doi]
AB  - BACKGROUND: Delayed paraplegia due to spinal cord ischemia/reperfusion injury 
      (IRI) remains one of the most severe complications of thoracoabdominal aneurysm 
      surgery, for which effective prevention and treatment is still lacking. 
      OBJECTIVES: The current study investigates whether spinal cord stimulation (SCS) 
      postconditioning has neuroprotective effects against spinal cord IRI. METHOD: 
      Ninety-six New Zealand white male rabbits were randomly divided into four groups 
      as follows: a sham group and three experimental groups (C group, 2 Hz group, and 
      50 Hz group) n = 24/group. Spinal cord ischemia was induced by transient 
      infrarenal aortic balloon occlusion for 28 min, after which rabbits in group C 
      underwent no additional intervention, while rabbits in the other two experimental 
      groups underwent 2 Hz or 50 Hz epidural SCS for 30 min at the onset of 
      reperfusion and then daily until sacrifice. Hind limb neurologic function of 
      rabbits was assessed using Jacob scale. Lumbar spinal cords were harvested 
      immediately after sacrifice for histological examination and terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. 
      The number of viable alpha-motor neurons in ventral horn was counted and 
      TUNEL-positive rate of alpha-motor neurons was calculated. RESULT: Spinal cord IRI 
      was caused by transient infrarenal aorta occlusion for 28 min. Both 2 Hz and 50 
      Hz SCS postconditioning had neuroprotective effects, particularly the 2 Hz SCS 
      postconditioning. Comparing to C group and 50 Hz group, rabbits in the 2 Hz group 
      demonstrated better hind limb motor function and a lower rate of TUNEL-positive 
      alpha-motor neuron after eight hours, one day, three days, and seven days of spinal 
      cord reperfusion. More viable alpha-motor neurons were preserved after one and three 
      days of spinal cord reperfusion in 2 Hz group rabbits than in C group and 50 Hz 
      group rabbits. CONCLUSION: SCS postconditioning at 2 Hz protected the spinal cord 
      from IRI.
CI  - (c) 2018 International Neuromodulation Society.
FAU - Li, Huixian
AU  - Li H
AD  - Department of Anesthesiology, Beijing Anzhen Hospital, Beijing Institute 
      of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 
      China.
FAU - Dong, Xiuhua
AU  - Dong X
AD  - Department of Anesthesiology, Beijing Anzhen Hospital, Beijing Institute 
      of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 
      China.
FAU - Jin, Mu
AU  - Jin M
AD  - Department of Anesthesiology, Beijing Anzhen Hospital, Beijing Institute 
      of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 
      China.
FAU - Cheng, Weiping
AU  - Cheng W
AD  - Department of Anesthesiology, Beijing Anzhen Hospital, Beijing Institute 
      of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180118
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Microglia/pathology
MH  - Motor Neurons/pathology
MH  - Neurologic Examination
MH  - Rabbits
MH  - Random Allocation
MH  - Reperfusion Injury/*prevention & control
MH  - Spinal Cord Ischemia/*prevention & control
MH  - Spinal Cord Stimulation/*methods
OTO - NOTNLM
OT  - Postconditioning
OT  - spinal cord ischemia-reperfusion injury
OT  - spinal cord stimulation
EDAT- 2018/01/19 06:00
MHDA- 2018/10/31 06:00
CRDT- 2018/01/19 06:00
PHST- 2017/09/21 00:00 [received]
PHST- 2017/11/05 00:00 [revised]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2018/01/19 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
PHST- 2018/01/19 06:00 [entrez]
AID - S1094-7159(21)02260-1 [pii]
AID - 10.1111/ner.12751 [doi]
PST - ppublish
SO  - Neuromodulation. 2018 Jul;21(5):448-456. doi: 10.1111/ner.12751. Epub 2018 Jan 
      18.