PMID- 29346609
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20220316
IS  - 1943-7730 (Electronic)
IS  - 0007-5027 (Linking)
VI  - 49
IP  - 2
DP  - 2018 Mar 21
TI  - Decreased Serum Levels of Ghrelin and Brain-Derived Neurotrophic Factor in 
      Premenopausal Women With Metabolic Syndrome.
PG  - 140-146
LID - 10.1093/labmed/lmx087 [doi]
AB  - OBJECTIVE: We aimed to investigate the association between serum levels of 
      ghrelin and brain-derived neurotrophic factor (BDNF) with MetS and its components 
      in premenopausal women. METHODS: 43 patients with MetS and 43 healthy controls 
      participated in this study. Participants' body mass index (BMI), waist 
      circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were 
      measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high 
      density lipoprotein cholesterol (LDL-C and HDL-C), fasting blood sugar (FBS), 
      insulin, BDNF and ghrelin determined. Homeostasis model assessment insulin 
      resistance index (HOMA-IR) was also calculated. RESULTS: Participants in MetS 
      group had higher waist-to-hip ratios, elevated SBP and DBP, and higher serum 
      levels of TG, FBS and insulin when compared with the control group. Serum ghrelin 
      and BDNF levels were significantly lower in participants with MetS than in the 
      healthier control subjects. There was a strong, positive correlation between 
      serum ghrelin and BDNF levels. Both proteins negatively correlated with TG, FBS, 
      HOMA-IR and positively with HDL-C. Furthermore, serum BDNF levels negatively 
      associated with insulin levels. CONCLUSIONS: The findings indicate that 
      variations occur in the circulating level of ghrelin and BDNF proteins in MetS 
      patients. A strong correlation between serum ghrelin and BDNF suggests that 
      production, release or practice of these 2 proteins might be related 
      mechanically.
FAU - Jabbari, Masoumeh
AU  - Jabbari M
AD  - Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Kheirouri, Sorayya
AU  - Kheirouri S
AD  - Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Alizadeh, Mohammad
AU  - Alizadeh M
AD  - Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lab Med
JT  - Laboratory medicine
JID - 0250641
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ghrelin)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Ghrelin/*blood
MH  - Humans
MH  - Metabolic Syndrome/*blood/*epidemiology
MH  - Middle Aged
MH  - Premenopause/*blood
EDAT- 2018/01/19 06:00
MHDA- 2018/05/31 06:00
CRDT- 2018/01/19 06:00
PHST- 2018/01/19 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
PHST- 2018/01/19 06:00 [entrez]
AID - 4807294 [pii]
AID - 10.1093/labmed/lmx087 [doi]
PST - ppublish
SO  - Lab Med. 2018 Mar 21;49(2):140-146. doi: 10.1093/labmed/lmx087.