PMID- 29346671 OWN - NLM STAT- MEDLINE DCOM- 20180529 LR - 20220316 IS - 1943-7730 (Electronic) IS - 0007-5027 (Linking) VI - 49 IP - 2 DP - 2018 Mar 21 TI - Hematological Analysis in Thai Samples With Deletional and Nondeletional HbH Diseases. PG - 154-159 LID - 10.1093/labmed/lmx068 [doi] AB - OBJECTIVES: To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. METHODS: Samples of 43 deletional HbH diseases, which included 39 --SEA/-alpha3.7, 4 - -SEA/-alpha4.2, and 22 nondeletional HbH diseases (- -SEA/alphacsalpha), were used in this study. Correlations between HbH levels and hematological parameters within these 2 groups were analyzed. RESULTS: The deletional HbH disease had higher levels of RBC counts, total Hb, pack cell volume (PCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), HbA, and HbA2 than did the nondeletional HbH disease. A negative correlation between HbH and RBC counts was detected in the group of deletional HbH disease, while a positive correlation between HbH and RBC counts, total Hb, and PCV was found in the group of nondeletional HbH disease. CONCLUSIONS: These results reflected that samples with nondeletional HbH showed more anemic features than those with the deletional HbH. FAU - Pornprasert, Sakorn AU - Pornprasert S AD - Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. FAU - Salaeh, Nur-Afsan AU - Salaeh NA AD - Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. FAU - Tookjai, Monthathip AU - Tookjai M AD - Associated Medical Sciences Clinical Service Center, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. FAU - Punyamung, Manoo AU - Punyamung M AD - Associated Medical Sciences Clinical Service Center, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. FAU - Pongpunyayuen, Panida AU - Pongpunyayuen P AD - Associated Medical Sciences Clinical Service Center, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. FAU - Treesuwan, Kallayanee AU - Treesuwan K AD - Associated Medical Sciences Clinical Service Center, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. LA - eng PT - Journal Article PL - England TA - Lab Med JT - Laboratory medicine JID - 0250641 RN - 9034-79-1 (Hemoglobin H) SB - IM MH - Hematologic Tests/*methods MH - Hemoglobin H/*analysis MH - Humans MH - Retrospective Studies MH - *alpha-Thalassemia/blood/diagnosis/epidemiology EDAT- 2018/01/19 06:00 MHDA- 2018/05/31 06:00 CRDT- 2018/01/19 06:00 PHST- 2018/01/19 06:00 [pubmed] PHST- 2018/05/31 06:00 [medline] PHST- 2018/01/19 06:00 [entrez] AID - 4807289 [pii] AID - 10.1093/labmed/lmx068 [doi] PST - ppublish SO - Lab Med. 2018 Mar 21;49(2):154-159. doi: 10.1093/labmed/lmx068.