PMID- 29347936
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181113
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Print)
IS  - 1465-9921 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Jan 18
TI  - Comparative analysis of COPD associated with tobacco smoking, biomass smoke 
      exposure or both.
PG  - 13
LID - 10.1186/s12931-018-0718-y [doi]
LID - 13
AB  - BACKGROUND: Exposure to noxious gases and particles contained in both tobacco 
      smoking (TS) and biomass smoke (BS) are well recognized environmental risk 
      factors for chronic obstructive pulmonary disease (COPD). COPD is characterized 
      by an abnormal inflammatory response, both in the pulmonary and systemic 
      compartments. The differential effects of TS, BS or their combined exposure have 
      not been well characterized yet. This study sought to compare the lung function 
      characteristics and systemic inflammatory response in COPD patients exposed to 
      TS, BS or their combination. METHODS: Sociodemographic, clinical and lung 
      functional parameters were compared across 49 COPD patients with a history of 
      smoking and no BS exposure (TS COPD), 31 never-smoker COPD patients with BS 
      exposure (BS COPD), 46 COPD patients with a combined exposure (TS + BS COPD) and 
      52 healthy controls (HC) who have never been exposed neither to TS or BS. Blood 
      cell counts, C-reactive protein (CRP), fibrinogen and immunoglobulin E (IgE) 
      levels were quantified in all four groups. RESULTS: TS + BS COPD patients 
      exhibited significantly lower oxygen saturation than the rest of groups 
      (p < 0.01). Spirometry and diffusing capacity were significantly higher in BS 
      than in TS or TS + BS patients. CRP levels were significantly higher in TS COPD 
      patients than in BS COPD group (p < 0.05), whereas fibrinogen was raised in COPD 
      patients with a history of smoking (TS and TS + BS) when compared to control 
      subjects (p < 0.01). Finally, COPD patients with BS exposure (BS and BS + TS 
      groups) showed higher IgE levels than TS and HC (p < 0.05). CONCLUSIONS: There 
      are significant physiological and inflammatory differences between COPD patients 
      with TS, BS and TS + BS exposures. The latter had worse blood oxygenation, 
      whereas the raised levels of IgE in BS exposed patients suggests a differential 
      Th2 systemic inflammatory pattern triggered by this pollutant.
FAU - Olloquequi, Jordi
AU  - Olloquequi J
AUID- ORCID: 0000-0002-6492-2739
AD  - Instituto de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad 
      Autonoma de Chile, 5 Poniente #1670, 3460000, Talca, Chile. jordiog82@gmail.com.
FAU - Jaime, Sergio
AU  - Jaime S
AD  - Unidad Respiratorio, Centro de Diagnostico Terapeutico, Hospital Regional de 
      Talca, 1 Norte #1990, 3460000, Talca, Chile.
FAU - Parra, Viviana
AU  - Parra V
AD  - Unidad Respiratorio, Centro de Diagnostico Terapeutico, Hospital Regional de 
      Talca, 1 Norte #1990, 3460000, Talca, Chile.
FAU - Cornejo-Cordova, Elizabeth
AU  - Cornejo-Cordova E
AD  - Subdepartamento de Salud Laboral, Hospital Regional de Talca, 1 Norte #1990, 
      3460000, Talca, Chile.
FAU - Valdivia, Gonzalo
AU  - Valdivia G
AD  - Departamento de Salud Publica, Facultad de Medicina, Pontificia Universidad 
      Catolica de Chile, Av. Libertador Bernardo O'Higgins #340, 35420000, Santiago, 
      Chile.
FAU - Agusti, Alvar
AU  - Agusti A
AD  - Respiratory Institute, Hospital Clinic, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS) Universitat de Barcelona, Rossello #149-153, 08036, 
      Barcelona, Catalonia, Spain.
FAU - Silva O, Rafael
AU  - Silva O R
AD  - Unidad Respiratorio, Centro de Diagnostico Terapeutico, Hospital Regional de 
      Talca, 1 Norte #1990, 3460000, Talca, Chile.
LA  - eng
GR  - FONDECYT#11150022/Comision Nacional de Investigacion Cientifica y 
      Tecnologica/International
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180118
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
RN  - 0 (Inflammation Mediators)
RN  - 0 (Smoke)
SB  - IM
EIN - Respir Res. 2018 Apr 30;19(1):77. PMID: 29712563
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biomass
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*blood/*diagnosis/physiopathology
MH  - Smoke/*adverse effects
MH  - Spirometry/methods/trends
MH  - Tobacco Smoking/*adverse effects/trends
PMC - PMC5774164
OTO - NOTNLM
OT  - Biomass smoke
OT  - COPD
OT  - Immunoglobulin E
OT  - Indoor pollution
OT  - Oxygen saturation
OT  - Systemic inflammation
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study protocols were approved by 
      the local ethics committees of the Maulean Health Service and Universidad 
      Autonoma de Chile. Informed written consent was obtained from all participants. 
      CONSENT OF PUBLICATION: Not available. COMPETING INTERESTS: The authors declare 
      that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains 
      neutral with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2018/01/20 06:00
MHDA- 2018/11/06 06:00
PMCR- 2018/01/18
CRDT- 2018/01/20 06:00
PHST- 2017/11/17 00:00 [received]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2018/01/20 06:00 [entrez]
PHST- 2018/01/20 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/01/18 00:00 [pmc-release]
AID - 10.1186/s12931-018-0718-y [pii]
AID - 718 [pii]
AID - 10.1186/s12931-018-0718-y [doi]
PST - epublish
SO  - Respir Res. 2018 Jan 18;19(1):13. doi: 10.1186/s12931-018-0718-y.