PMID- 29347948 OWN - NLM STAT- MEDLINE DCOM- 20181217 LR - 20220331 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 17 IP - 1 DP - 2018 Jan 18 TI - Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study. PG - 9 LID - 10.1186/s12940-017-0338-x [doi] LID - 9 AB - BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. METHODS: Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) >/= 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. RESULTS: In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (beta = 0.18, 95% CI: 0.01-0.35), and increased triceps skinfold z-score (beta = 0.15, 95% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI >/= 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. CONCLUSION: We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants. FAU - Lauritzen, Hilde B AU - Lauritzen HB AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. hilde.b.lauritzen@ntnu.no. FAU - Larose, Tricia L AU - Larose TL AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. FAU - Oien, Torbjorn AU - Oien T AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. FAU - Sandanger, Torkjel M AU - Sandanger TM AD - Department of Community Medicine, University of Tromso - The Arctic University of Norway, Tromso, Norway. AD - NILU-Norwegian Institute for Air Research, Fram High north research Centre for Climate and the Environment, Tromso, Norway. FAU - Odland, Jon O AU - Odland JO AD - Department of Community Medicine, University of Tromso - The Arctic University of Norway, Tromso, Norway. AD - School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa. FAU - van de Bor, Margot AU - van de Bor M AD - Department of Environment and Health, VU University, Amsterdam, The Netherlands. FAU - Jacobsen, Geir W AU - Jacobsen GW AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180118 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Environmental Pollutants) SB - IM MH - Adult MH - Body Mass Index MH - Child, Preschool MH - Environmental Pollutants/*blood MH - Female MH - Humans MH - *Maternal Exposure MH - Norway/epidemiology MH - Overweight/chemically induced/*epidemiology MH - Pediatric Obesity/chemically induced/*epidemiology MH - Pregnancy MH - Prenatal Exposure Delayed Effects/chemically induced/*epidemiology MH - Prevalence MH - Sweden/epidemiology MH - Young Adult PMC - PMC5774128 OTO - NOTNLM OT - Childhood obesity OT - Endocrine disrupting chemicals OT - Non-monotonic dose-response relationship OT - Organochlorines OT - Perfluoroalkyl substances OT - Pregnancy OT - Skinfolds COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All participants provided written informed consent for continued use of data and biomaterial, which was documented at the first study visit. The study, including the consent procedure, has been reviewed and approved by the Central Norway Regional Committee for Medical and Health Sciences Research Ethics (REK Midt 2010/1449-5). CONSENT FOR PUBLICATION: N/A. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/01/20 06:00 MHDA- 2018/12/18 06:00 PMCR- 2018/01/18 CRDT- 2018/01/20 06:00 PHST- 2017/07/14 00:00 [received] PHST- 2017/11/03 00:00 [accepted] PHST- 2018/01/20 06:00 [entrez] PHST- 2018/01/20 06:00 [pubmed] PHST- 2018/12/18 06:00 [medline] PHST- 2018/01/18 00:00 [pmc-release] AID - 10.1186/s12940-017-0338-x [pii] AID - 338 [pii] AID - 10.1186/s12940-017-0338-x [doi] PST - epublish SO - Environ Health. 2018 Jan 18;17(1):9. doi: 10.1186/s12940-017-0338-x.