PMID- 29349656
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20181113
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 39
IP  - 3
DP  - 2018 Mar
TI  - Correlations among multifocal electroretinography and optical coherence 
      tomography findings in patients with Parkinson's disease.
PG  - 533-541
LID - 10.1007/s10072-018-3244-2 [doi]
AB  - To assess the correlation between functional and anatomical evaluations with 
      multifocal electroretinography (mfERG) and spectral-domain optical coherence 
      tomography (SD-OCT) in patients with Parkinson's disease (PD). This 
      cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and 
      sex-matched control subjects. All study participants underwent a comprehensive 
      neuro-ophthalmic examination, retinal single-layer thicknesses and volumes, and 
      peripapillary retinal nerve fiber layer (pRNFL) measurements with SD-OCT, and the 
      patients' mfERG recordings were evaluated. The macular retinal nerve fiber layer 
      (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), outer nuclear 
      layer (ONL), retinal pigment epithelium (RPE), and photoreceptor layer (PR) 
      thicknesses, and mRNFL, RPE, and PR volumes were found lower in PD compared to 
      those of controls, while outer plexiform layer (OPL) volumes were increased 
      (p < 0.05). We found delayed implicit times and decreased amplitudes in the mfERG 
      of PD patients versus those in control subjects (p < 0.05). We found significant 
      correlations between outer macular volumes, PR thicknesses, and N1 amplitudes of 
      rings 2 and 3and P1 amplitudes of rings 3, 4, and 5. Our study revealed thinning 
      of both inner and outer retinal single layers, increased OPL volume, and delayed 
      implicit times and decreased amplitudes in the mfERG of PD patients versus 
      control subjects and correlation between structural and functional parameters. 
      Our findings point out that SD-OCT and mfERG could both serve as non-invasive 
      tools for evaluating ophthalmic manifestations of Parkinson's disease.
FAU - Unlu, Metin
AU  - Unlu M
AUID- ORCID: 0000-0003-2505-9853
AD  - School of Medicine, Ophthalmology Department, Erciyes University, 38039, Kayseri, 
      Turkey. drunlumetin@hotmail.com.
FAU - Gulmez Sevim, Duygu
AU  - Gulmez Sevim D
AD  - School of Medicine, Ophthalmology Department, Erciyes University, 38039, Kayseri, 
      Turkey.
FAU - Gultekin, Murat
AU  - Gultekin M
AD  - School of Medicine, Neurology Department, Erciyes University, 38039, Kayseri, 
      Turkey.
FAU - Karaca, Cagatay
AU  - Karaca C
AD  - School of Medicine, Ophthalmology Department, Erciyes University, 38039, Kayseri, 
      Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180118
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Electroretinography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Parkinson Disease/*diagnostic imaging/pathology/physiopathology
MH  - Retina/*diagnostic imaging/pathology/physiopathology
MH  - *Tomography, Optical Coherence
OTO - NOTNLM
OT  - Multifocal electroretinography
OT  - Optical coherence tomography
OT  - Parkinson's disease
OT  - Retinal nerve fiber layer
OT  - Retinal single layers
EDAT- 2018/01/20 06:00
MHDA- 2018/08/31 06:00
CRDT- 2018/01/20 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2018/01/02 00:00 [accepted]
PHST- 2018/01/20 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
PHST- 2018/01/20 06:00 [entrez]
AID - 10.1007/s10072-018-3244-2 [pii]
AID - 10.1007/s10072-018-3244-2 [doi]
PST - ppublish
SO  - Neurol Sci. 2018 Mar;39(3):533-541. doi: 10.1007/s10072-018-3244-2. Epub 2018 Jan 
      18.