PMID- 29350074
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20200205
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 46
IP  - 4
DP  - 2018 Apr
TI  - Serum concentration and clinical significance of brain-derived neurotrophic 
      factor in patients with Parkinson's disease or essential tremor.
PG  - 1477-1485
LID - 10.1177/0300060517748843 [doi]
AB  - Objectives The serum concentration of brain-derived neurotrophic factor (BDNF) 
      was compared among patients with Parkinson's disease (PD), patients with 
      essential tremor (ET), and healthy participants, and its association with 
      clinical features of PD and ET was assessed. Methods Demographic and clinical 
      data were collected from 60 patients with PD at different clinical stages, 60 
      patients with ET, and 60 controls. All participants' serum BDNF concentrations 
      were measured. Their motor abilities and activity were assessed by the Unified PD 
      Rating Scale and the Hoehn and Yahr (H-Y) staging scale. Results Serum BDNF was 
      significantly lower in patients with PD than in patients with ET and controls. 
      BDNF decreased only in the early disease stages (H-Y stages I and II), but 
      increased markedly in the advanced stages (H-Y stages III-V). There was no 
      significant difference between patients with ET and controls. The BDNF 
      concentration was negatively correlated with age at PD onset and positively 
      associated with disease duration, severity of PD symptoms, and treatment with 
      L-DOPA. Conclusions A low serum BDNF concentration may serve as a biomarker in 
      the early stages of PD, whereas a high concentration with PD progression may be 
      due to treatment with L-DOPA in the advanced stages.
FAU - Huang, Yixian
AU  - Huang Y
AD  - 1 Department of Neurology, The Second Affiliated Hospital of Soochow University, 
      No. 1055 Sanxiang Road, Suzhou, China.
FAU - Yun, Wenwei
AU  - Yun W
AD  - 3 Laboratory of Neurological Diseases, Department of Neurology, Changzhou No. 2 
      People's Hospital, The Affiliated Hospital of Nanjing Medical University, 29 
      Xinglong Alley, Changzhou, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - 3 Laboratory of Neurological Diseases, Department of Neurology, Changzhou No. 2 
      People's Hospital, The Affiliated Hospital of Nanjing Medical University, 29 
      Xinglong Alley, Changzhou, China.
FAU - Luo, Weifeng
AU  - Luo W
AD  - 1 Department of Neurology, The Second Affiliated Hospital of Soochow University, 
      No. 1055 Sanxiang Road, Suzhou, China.
AD  - 2 Institute of Neuroscience, Soochow University, Suzhou, China.
FAU - Zhou, Xianju
AU  - Zhou X
AD  - 3 Laboratory of Neurological Diseases, Department of Neurology, Changzhou No. 2 
      People's Hospital, The Affiliated Hospital of Nanjing Medical University, 29 
      Xinglong Alley, Changzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20180119
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Demography
MH  - Essential Tremor/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*blood
PMC - PMC6091839
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Hoehn and Yahr staging scale
OT  - L-DOPA
OT  - Parkinson's disease
OT  - biomarker
OT  - essential tremor
EDAT- 2018/01/20 06:00
MHDA- 2018/09/11 06:00
PMCR- 2018/01/19
CRDT- 2018/01/20 06:00
PHST- 2018/01/20 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2018/01/20 06:00 [entrez]
PHST- 2018/01/19 00:00 [pmc-release]
AID - 10.1177_0300060517748843 [pii]
AID - 10.1177/0300060517748843 [doi]
PST - ppublish
SO  - J Int Med Res. 2018 Apr;46(4):1477-1485. doi: 10.1177/0300060517748843. Epub 2018 
      Jan 19.