PMID- 29350388
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 76
IP  - 3
DP  - 2018
TI  - Chronic statin treatment is a predictor of pre-interventional infarct-related 
      artery patency in patients with ST elevation myocardial infarction treated with 
      percutaneous coronary intervention.
PG  - 542-547
LID - 10.5603/KP.a2017.0247 [doi]
AB  - BACKGROUND: Beyond lipid-lowering effects, early statin treatment has beneficial 
      effects on prognosis after acute coronary syndrome. Infarct-related artery (IRA) 
      patency before percutaneous coronary intervention (PCI) is known to be a strong 
      pre-dictor of improved clinical outcome. AIM: We aimed to investigate the effects 
      of chronic statin treatment before admission on IRA patency after myocardial 
      infarction. METHODS: In this study, 938 ST elevation myocardial infarction 
      (STEMI) patients admitted to the hospital within the first 12 h of symptom onset 
      were prospectively enrolled (male, n = 682; female, n = 256; mean age 58.6 +/- 12.4 
      years). All patients underwent emergent primary PCI. Patients were divided into 
      two groups based upon angiographic IRA patency. Impaired IRA patency was defined 
      as Thrombolysis In Myocardial Infarction (TIMI) grade 0 and 1 flow (non-patent 
      IRA group). Angiographic IRA patency was defined as TIMI 2 and 3 flow (patent IRA 
      group). RESULTS: Previous statin usage was more frequent in the patent IRA group 
      (n = 138; 71.9%), than in the non-patent IRA group (n = 110; 14.7%; p < 0.001). 
      Pre-PCI IRA patency was independently associated with body mass index (odds 
      ra-tio [OR] = 1.087, 95% confidence interval [CI] 1.005-1.176, p < 0.001), 
      previous chronic statin use (OR 0.065, 95% CI 0.043-0.098, p = 0.039), ejection 
      fraction (OR 1.041, 95% CI 1.018-1.064, p < 0.001), and SYNTAX score (OR 0.927, 
      95% CI 0.899-0.957, p < 0.001) in multivariate logistic regression analysis. 
      CONCLUSIONS: Chronic pre-treatment with statins is a significant predictor of the 
      IRA patency in patients with STEMI.
FAU - Ozbicer, Suleyman
AU  - Ozbicer S
AD  - Adana Numune Education and Research Hospital, Adana, Turkey. 
      suleymanozbicer@gmail.com.
FAU - Gur, Mustafa
AU  - Gur M
FAU - Kalkan, Gulhan
AU  - Kalkan G
FAU - Ozaltun, Betul
AU  - Ozaltun B
FAU - Cayli, Murat
AU  - Cayli M
LA  - eng
PT  - Journal Article
DEP - 20180119
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Prognosis
MH  - ST Elevation Myocardial Infarction/*surgery
OTO - NOTNLM
OT  - TIMI flow
OT  - infarct-related artery patency
OT  - myocardial infarction
OT  - statin
EDAT- 2018/01/20 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/01/20 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/10/12 00:00 [accepted]
PHST- 2017/10/15 00:00 [revised]
PHST- 2018/01/20 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/01/20 06:00 [entrez]
AID - VM/OJS/KP/11547 [pii]
AID - 10.5603/KP.a2017.0247 [doi]
PST - ppublish
SO  - Kardiol Pol. 2018;76(3):542-547. doi: 10.5603/KP.a2017.0247. Epub 2018 Jan 19.