PMID- 29351277
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20231105
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Ex-ante assessment of different vaccination-based control schedules against the 
      peste des petits ruminants virus in sub-Saharan Africa.
PG  - e0190296
LID - 10.1371/journal.pone.0190296 [doi]
LID - e0190296
AB  - BACKGROUND: Peste des petits ruminants (PPR) is a highly contagious and 
      widespread viral infection of small ruminants (goats and sheep), causing heavy 
      economic losses in many developing countries. Therefore, its progressive control 
      and global eradication by 2030 was defined as a priority by international 
      organizations addressing animal health. The control phase of the global strategy 
      is based on mass vaccination of small ruminant populations in endemic regions or 
      countries. It is estimated that a 70% post-vaccination immunity rate (PVIR) is 
      needed in a given epidemiological unit to prevent PPR virus spread. However, 
      implementing mass vaccination is difficult and costly in smallholder farming 
      systems with scattered livestock and limited facilities. Regarding this, 
      controlling PPR is a special challenge in sub-Saharan Africa. In this study, we 
      focused on this region to assess the effect of several variables of PVIR in two 
      contrasted smallholder farming systems. METHODS: Using a seasonal matrix 
      population model of PVIR, we estimated its decay in goats reared in sub-humid 
      areas, and sheep reared in semi-arid areas, over a 4-year vaccination program. 
      Assuming immunologically naive and PPR-free epidemiological unit, we assessed the 
      ability of different vaccination scenarios to reach the 70% PVIR throughout the 
      program. The tested scenarios differed in i) their overall schedule, ii) their 
      delivery month and iii) their vaccination coverage. RESULTS: In sheep reared in 
      semi-arid areas, the vaccination month did affect the PVIR decay though it did 
      not in goats in humid regions. In both cases, our study highlighted i) the 
      importance of targeting the whole eligible population at least during the two 
      first years of the vaccination program and ii) the importance of reaching a 
      vaccination coverage as high as 80% of this population. This study confirmed the 
      relevance of the vaccination schedules recommended by international 
      organizations.
FAU - Hammami, Pachka
AU  - Hammami P
AUID- ORCID: 0000-0002-7490-6257
AD  - UMR 117 Animals, Health, Territories, Risks and Ecosystems (ASTRE), Centre de 
      cooperation internationale en recherche agronomique pour le developpement 
      (CIRAD), Campus international de Baillarguet, 34398 Montpellier, France.
AD  - UMR 117 ASTRE, Institut national de la recherche agronomique (INRA), Campus 
      international de Baillarguet, 34398 Montpellier, France.
FAU - Lancelot, Renaud
AU  - Lancelot R
AD  - UMR 117 Animals, Health, Territories, Risks and Ecosystems (ASTRE), Centre de 
      cooperation internationale en recherche agronomique pour le developpement 
      (CIRAD), Campus international de Baillarguet, 34398 Montpellier, France.
AD  - UMR 117 ASTRE, Institut national de la recherche agronomique (INRA), Campus 
      international de Baillarguet, 34398 Montpellier, France.
FAU - Domenech, Joseph
AU  - Domenech J
AD  - Consultant, La Fabreguerie, 12170, Ledergues, France.
FAU - Lesnoff, Matthieu
AU  - Lesnoff M
AD  - UMR Systemes d'elevage mediterraneens et tropicaux (SELMET), CIRAD, Campus 
      international de Baillarguet, 34398 Montpellier, France.
AD  - UMR SELMET, INRA, Campus international de Baillarguet, 34398 Montpellier, France.
AD  - UMR SELMET, Montpellier SUPAGRO, Campus international de Baillarguet, 34398 
      Montpellier, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180119
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Africa South of the Sahara
MH  - Animals
MH  - Goat Diseases/*prevention & control
MH  - Goats
MH  - *Immunization Schedule
MH  - Peste-des-Petits-Ruminants/*prevention & control
MH  - Peste-des-petits-ruminants virus/*immunology
MH  - Sheep
MH  - Sheep Diseases/*prevention & control
MH  - Viral Vaccines/*administration & dosage
PMC - PMC5774693
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2018/01/20 06:00
MHDA- 2018/02/16 06:00
PMCR- 2018/01/19
CRDT- 2018/01/20 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/01/20 06:00 [entrez]
PHST- 2018/01/20 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2018/01/19 00:00 [pmc-release]
AID - PONE-D-17-06119 [pii]
AID - 10.1371/journal.pone.0190296 [doi]
PST - epublish
SO  - PLoS One. 2018 Jan 19;13(1):e0190296. doi: 10.1371/journal.pone.0190296. 
      eCollection 2018.