PMID- 29352445
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20201209
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 64
IP  - 3
DP  - 2018 Mar
TI  - Effect of Sevoflurane Anesthesia on Brain Is Mediated by lncRNA HOTAIR.
PG  - 346-351
LID - 10.1007/s12031-018-1029-y [doi]
AB  - Postoperative cognitive dysfunction in elderly patients has been related to 
      neurodegenerative disorders and mortality. Sevoflurane anesthesia has been 
      implicated in both postoperative cognitive dysfunction and neurotoxicity. Given 
      the advantages of using inhaled anesthetics like sevoflurane, it is important to 
      understand how their usage results in neurotoxicity and subsequently devise ways 
      to circumvent or attenuate the anesthetic-mediated induction in neurotoxicity. 
      Long noncoding RNAs (LncRNAs) are a group of > 200 bp long RNAs and show specific 
      spatiotemporal expression profiles. Several recent reports suggest that lncRNAs 
      are involved in responses of the central nervous system (CNS) following acute 
      injuries. However, their role in sevoflurane anesthesia-mediated cognitive 
      dysfunction has not been studied. RNA immunoprecipitation (RIP) combined with 
      qRT-PCR detection of six different lncRNAs showed that the HOTAIR lncRNAs were 
      significantly more bound to both Sin3A and coREST, both corepressors of the RE-1 
      silencing transcription factor, within rat hippocampus following sevoflurane 
      anesthesia compared with sham. Sevoflurane inhalation resulted in significant 
      inhibition of brain-derived neurotrophic factor (BDNF) and cognitive impairment. 
      Treatment with a combination of siRNAs targeting HOTAIR rescued BDNF expression 
      and improved cognitive responses. Taken together, our results suggest that 
      sevoflurane-mediated brain function impairment is at least in part mediated by 
      the HOTAIR lncRNA.
FAU - Wang, Jian-Yue
AU  - Wang JY
AUID- ORCID: 0000-0001-9799-0191
AD  - Department of Anesthesiology, Binzhou People's Hospital, No.515, Huangheqi Road, 
      Binzhou, Shandong, 256610, China. sdbzwjy@126.com.
FAU - Feng, Yong
AU  - Feng Y
AD  - Department of Anesthesiology, Binzhou People's Hospital, No.515, Huangheqi Road, 
      Binzhou, Shandong, 256610, China.
FAU - Fu, Yan-Hong
AU  - Fu YH
AD  - Department of Anesthesiology, Binzhou People's Hospital, No.515, Huangheqi Road, 
      Binzhou, Shandong, 256610, China.
FAU - Liu, Guang-Li
AU  - Liu GL
AD  - Department of Anesthesiology, Binzhou People's Hospital, No.515, Huangheqi Road, 
      Binzhou, Shandong, 256610, China.
LA  - eng
PT  - Journal Article
DEP - 20180119
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Co-Repressor Proteins)
RN  - 0 (CoREST protein, rat)
RN  - 0 (HOTAIR long untranslated RNA, rat)
RN  - 0 (Methyl Ethers)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Repressor Proteins)
RN  - 0 (SIN3A transcription factor)
RN  - 38LVP0K73A (Sevoflurane)
RN  - EC 3.5.1.98 (Sin3 Histone Deacetylase and Corepressor Complex)
SB  - IM
MH  - Anesthetics, Inhalation/*pharmacology
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Co-Repressor Proteins/genetics/metabolism
MH  - Male
MH  - Methyl Ethers/*pharmacology
MH  - RNA, Long Noncoding/*genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Repressor Proteins/genetics/metabolism
MH  - Sevoflurane
MH  - Sin3 Histone Deacetylase and Corepressor Complex
OTO - NOTNLM
OT  - Cognitive impairment
OT  - HOTAIR
OT  - Long noncoding RNA
OT  - Sevoflurane
EDAT- 2018/01/21 06:00
MHDA- 2018/09/06 06:00
CRDT- 2018/01/21 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2018/01/10 00:00 [accepted]
PHST- 2018/01/21 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2018/01/21 06:00 [entrez]
AID - 10.1007/s12031-018-1029-y [pii]
AID - 10.1007/s12031-018-1029-y [doi]
PST - ppublish
SO  - J Mol Neurosci. 2018 Mar;64(3):346-351. doi: 10.1007/s12031-018-1029-y. Epub 2018 
      Jan 19.