PMID- 29353040
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20221207
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 496
IP  - 2
DP  - 2018 Feb 5
TI  - Eupatilin, an activator of PPARalpha, inhibits the development of oxazolone-induced 
      atopic dermatitis symptoms in Balb/c mice.
PG  - 508-514
LID - S0006-291X(18)30113-X [pii]
LID - 10.1016/j.bbrc.2018.01.098 [doi]
AB  - Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic 
      flavonoid obtained from the Artemisia species. Eupatilin has been reported to 
      have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, 
      we found that eupatilin increases transcriptional activity and expression of 
      peroxisome proliferator-activated receptor alpha (PPARalpha) in a keratinocyte cell line 
      and acts as an agonist of PPARalpha. PPARalpha agonists ameliorate atopic dermatitis (AD) 
      and restore the skin barrier function. In this study, we confirmed that the 
      effects of eupatilin improved AD-like symptoms in an oxazolone-induced AD-like 
      mouse model. Furthermore, we found that eupatilin suppressed the levels of serum 
      immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as 
      tumor necrosis factor alpha (TNFalpha), interferon-gamma (IFN-gamma), IL-1beta, and thymic stromal 
      lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and 
      loricrin in the oxazolone-induced AD-like mouse model. Taken together, our data 
      suggest that eupatilin is a potential candidate for the treatment of AD.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Jung, Yujung
AU  - Jung Y
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea.
FAU - Kim, Jin-Chul
AU  - Kim JC
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea.
FAU - Park, No-June
AU  - Park NJ
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea.
FAU - Bong, Sim-Kyu
AU  - Bong SK
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea.
FAU - Lee, Sullim
AU  - Lee S
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea.
FAU - Jegal, Hyun
AU  - Jegal H
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea.
FAU - Jin, Li Tai
AU  - Jin LT
AD  - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology Pharmaceutical 
      Engineering, Wenzhou Medical University, Wenzhou 325000, China.
FAU - Kim, Sang Moo
AU  - Kim SM
AD  - Department of Marine Food Science and Technology, Gangneung-Wonju National 
      University, Gangneung, Gangwon-do 25457, Republic of Korea.
FAU - Kim, Yong Kee
AU  - Kim YK
AD  - College of Pharmacy, Sookmyung Women's University, Seoul 04310, Republic of 
      Korea.
FAU - Kim, Su-Nam
AU  - Kim SN
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung, Gangwon-do 25451, Republic of Korea. Electronic address: 
      snkim@kist.re.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180117
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Cytokines)
RN  - 0 (Dermatologic Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Filaggrin Proteins)
RN  - 0 (Flavonoids)
RN  - 0 (IL1B protein, mouse)
RN  - 0 (Il33 protein, mouse)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-33)
RN  - 0 (Interleukins)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mydgf protein, mouse)
RN  - 0 (PPAR alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (loricrin)
RN  - 15646-46-5 (Oxazolone)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4D58O05490 (eupatilin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cytokines/genetics/immunology
MH  - Dermatitis, Atopic/chemically induced/*drug therapy/immunology/pathology
MH  - Dermatologic Agents/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Filaggrin Proteins
MH  - Flavonoids/*pharmacology
MH  - Gene Expression Regulation
MH  - Immunoglobulin E/blood/genetics
MH  - Interferon-gamma/genetics/immunology
MH  - Interleukin-1beta/genetics/immunology
MH  - Interleukin-33/genetics/immunology
MH  - Interleukin-4/genetics/immunology
MH  - Interleukins/genetics/immunology
MH  - Intermediate Filament Proteins/genetics/immunology
MH  - Membrane Proteins/genetics/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oxazolone
MH  - PPAR alpha/*genetics/immunology
MH  - Rats
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
MH  - Thymic Stromal Lymphopoietin
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Eupatilin
OT  - IL-4
OT  - PPARalpha
EDAT- 2018/01/22 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/01/22 06:00
PHST- 2017/12/29 00:00 [received]
PHST- 2018/01/15 00:00 [accepted]
PHST- 2018/01/22 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2018/01/22 06:00 [entrez]
AID - S0006-291X(18)30113-X [pii]
AID - 10.1016/j.bbrc.2018.01.098 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2018 Feb 5;496(2):508-514. doi: 
      10.1016/j.bbrc.2018.01.098. Epub 2018 Jan 17.