PMID- 29353097
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20211204
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 17
IP  - 3
DP  - 2018 Mar
TI  - Genetics of immunoglobulin-A vasculitis (Henoch-Schonlein purpura): An updated 
      review.
PG  - 301-315
LID - S1568-9972(18)30012-0 [pii]
LID - 10.1016/j.autrev.2017.11.024 [doi]
AB  - Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood 
      vessel vasculitis with predominant involvement of the skin. Gastrointestinal and 
      joint manifestations are common in patients diagnosed with this condition. 
      Nephritis, which is more severe in adults, constitutes the most feared 
      complication of this vasculitis. The molecular bases underlying the origin of 
      IgAV have not been completely elucidated. Nevertheless, several pieces of 
      evidence support the claim that genes play a crucial role in the pathogenesis of 
      this disease. The human leukocyte antigen (HLA) region is, until now, the main 
      genetic factor associated with IgAV pathogenesis. Besides a strong association 
      with HLA class II alleles, specifically HLA-DRB1 alleles, HLA class I alleles 
      also seem to influence on the predisposition of this disease. Other gene 
      polymorphisms located outside the HLA region, including those coding cytokines, 
      chemokines, adhesion molecules as well as those related to T-cells, aberrant 
      glycosylation of IgA1, nitric oxide production, neoangiogenesis, 
      renin-angiotensin system and lipid, Pyrin and homocysteine metabolism, may be 
      implicated not only in the predisposition to IgAV but also in its severity. An 
      update of the current knowledge of the genetic component associated with the 
      pathogenesis of IgAV is detailed in this review.
CI  - Copyright (c) 2018 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Lopez-Mejias, Raquel
AU  - Lopez-Mejias R
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain. 
      Electronic address: rlopezmejias78@gmail.com.
FAU - Castaneda, Santos
AU  - Castaneda S
AD  - Division of Rheumatology, Hospital Universitario de la Princesa, IIS-IPrincesa, 
      Madrid, Spain.
FAU - Genre, Fernanda
AU  - Genre F
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain.
FAU - Remuzgo-Martinez, Sara
AU  - Remuzgo-Martinez S
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain.
FAU - Carmona, F David
AU  - Carmona FD
AD  - Instituto de Parasitologia y Biomedicina 'Lopez-Neyra', CSIC, PTS Granada, 
      Granada, Spain; Departamento de Genetica e Instituto de Biotecnologia, 
      Universidad de Granada, Granada, Spain.
FAU - Llorca, Javier
AU  - Llorca J
AD  - Division of Epidemiology and Computational Biology, School of Medicine, 
      University of Cantabria, CIBER Epidemiologia y Salud Publica (CIBERESP), IDIVAL, 
      Santander, Spain.
FAU - Blanco, Ricardo
AU  - Blanco R
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain.
FAU - Martin, Javier
AU  - Martin J
AD  - Instituto de Parasitologia y Biomedicina 'Lopez-Neyra', CSIC, PTS Granada, 
      Granada, Spain.
FAU - Gonzalez-Gay, Miguel A
AU  - Gonzalez-Gay MA
AD  - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic 
      Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain; School of 
      Medicine, University of Cantabria, Santander, Spain; Cardiovascular 
      Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of 
      Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. 
      Electronic address: miguelaggay@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180117
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Humans
MH  - IgA Vasculitis/*genetics
MH  - Immunoglobulin A/*genetics/immunology
MH  - Polymorphism, Genetic/*genetics
OTO - NOTNLM
OT  - Genetics
OT  - Henoch-Schonlein purpura
OT  - Immunoglobulin-A vasculitis
EDAT- 2018/01/22 06:00
MHDA- 2018/05/22 06:00
CRDT- 2018/01/22 06:00
PHST- 2017/11/11 00:00 [received]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2018/01/22 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2018/01/22 06:00 [entrez]
AID - S1568-9972(18)30012-0 [pii]
AID - 10.1016/j.autrev.2017.11.024 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2018 Mar;17(3):301-315. doi: 10.1016/j.autrev.2017.11.024. Epub 
      2018 Jan 17.