PMID- 29353494
OWN - NLM
STAT- MEDLINE
DCOM- 20180824
LR  - 20181113
IS  - 1526-2359 (Electronic)
IS  - 1073-2748 (Print)
IS  - 1073-2748 (Linking)
VI  - 25
IP  - 1
DP  - 2018 Jan-Mar
TI  - Primary Liver Cancers, Part 2: Progression Pathways and Carcinogenesis.
PG  - 1073274817744658
LID - 10.1177/1073274817744658 [doi]
LID - 1073274817744658
AB  - Hepatocellular carcinoma (HCC) and primary intrahepatic cholangiocarcinoma (ICC) 
      have been increasing in incidence worldwide and are leading causes of cancer 
      death. Studies of the molecular alterations leading to these carcinomas provide 
      insights into the key mechanisms involved. A literature review was conducted to 
      identify articles with information relevant to current understanding of the 
      etiologies and molecular pathogenesis of HCC and ICC. Chronic inflammatory 
      diseases are the key etiological risk factors for both HCC and ICC, although 
      other diseases play a role, and for many ICCs, an underlying risk factor is not 
      identified. Mutations in catenin beta 1 ( CTNBB1) and tumor protein 53 (P53) are 
      the main genetic alterations in HCC. Isocitrate dehydrogenases 1 and 2 (IDH1/2), 
      KRAS protooncogene GTPase (KRAS), a RAS Viral Oncogene Homolog in neoroblastoma 
      (NRAS) and P53 are primary genetic alterations in ICC. In both diseases, the 
      mutational landscape is dependent on the underlying etiology. The most 
      significant etiologies and genetic processes involved in the carcinogenesis of 
      HCC and ICC are reviewed.
FAU - Jiang, Kun
AU  - Jiang K
AD  - 1 Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL, USA.
AD  - 2 Department of Oncologic Sciences, Morsani College of Medicine at University of 
      South Florida, Tampa, FL, USA.
FAU - Centeno, Barbara A
AU  - Centeno BA
AD  - 1 Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL, USA.
AD  - 2 Department of Oncologic Sciences, Morsani College of Medicine at University of 
      South Florida, Tampa, FL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Control
JT  - Cancer control : journal of the Moffitt Cancer Center
JID - 9438457
SB  - IM
CIN - Cancer Control. 25.
MH  - Carcinoma, Hepatocellular/*diagnosis/pathology
MH  - Cholangiocarcinoma/*diagnosis/pathology
MH  - Humans
MH  - Liver Neoplasms/*diagnosis/pathology
MH  - Risk Factors
PMC - PMC5933573
OTO - NOTNLM
OT  - carcinogenesis
OT  - cholangiocarcinoma
OT  - hepatocellular carcinoma
OT  - liver
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/01/23 06:00
MHDA- 2018/08/25 06:00
PMCR- 2018/01/22
CRDT- 2018/01/23 06:00
PHST- 2018/01/23 06:00 [entrez]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/08/25 06:00 [medline]
PHST- 2018/01/22 00:00 [pmc-release]
AID - 10.1177_1073274817744658 [pii]
AID - 10.1177/1073274817744658 [doi]
PST - ppublish
SO  - Cancer Control. 2018 Jan-Mar;25(1):1073274817744658. doi: 
      10.1177/1073274817744658.