PMID- 29353497
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20180402
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 159
IP  - 4
DP  - 2018 Jan
TI  - [The significance of N-terminal pro-B natriuretic peptide in the management of 
      adult patients with congenital heart disease - Results from the CSONGRAD 
      Registry].
PG  - 141-148
LID - 10.1556/650.2018.30942 [doi]
AB  - INTRODUCTION: The prognostic role of B-type natriuretic peptide (BNP) level was 
      confirmed in chronic heart failure and congenital heart diseases irrespective of 
      the aetiology. AIM: The aim of this study was to compare NT‑proBNP measured in 
      the clinical practice and important clinical and echocardiographic parameters in 
      patients with adult congenital heart diseases under our care. METHOD: Data of a 
      total of 70 patients were analysed; 34 patients had corrected tetralogy of Fallot 
      and 19 patients had corrected transposition of the great arteries. In 17 further 
      cases, patients with other congenital vitiums have been involved in the study. In 
      all cases, out-patient examination was performed with electrocardiography, 
      echocardiography and NT-proBNP measurement. The New York Heart Association (NYHA) 
      stages of the patients were determined and the patients filled in a questionnaire 
      regarding their quality of life. RESULTS: Elevated NT-proBNP level resulted in a 
      worse quality of life (visual analogue scale, VAS) and an increased right 
      ventricular end diastolic diameter; the incidence of arrhythmia increased as 
      well. Negative correlation was found between the NT-proBNP level and the VAS 
      value (r = -0.45, p = 0.0001) and the left ventricular ejection fraction (LV-EF) 
      (r = -0.67, p = <0.0001). ROC analysis showed that NT‑proBNP>/=668.1 pg/ml was the 
      cut-off value that most accurately predicted NYHA class III-IV (sensitivity 93%, 
      specificity 63%, area under the curve 80%, p = 0.001). Similarly, NT-proBNP>/=184.7 
      pg/ml was found to be the cut-off value most accurately predicting LV-EF below 
      55% (sensitivity 66%, specificity 67%, area under the curve 77%, p = 0.02). 
      CONCLUSIONS: NT-proBNP has a role in the evaluation of adult patients with 
      congenital heart diseases and in determining the prognosis of these patients, and 
      in addition to other examinations used in the follow-up of these patients, 
      NT-proBNP may help in determining the time of reoperation or potential heart 
      transplantation. Orv Hetil. 2018; 159(4): 141-148.
FAU - Ambrus, Nora
AU  - Ambrus N
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szegedi Tudomanyegyetem, 
      Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert Klinikai Kozpont Szeged, 
      Semmelweis u. 8., 6725.
FAU - Havasi, Kalman
AU  - Havasi K
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szegedi Tudomanyegyetem, 
      Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert Klinikai Kozpont Szeged, 
      Semmelweis u. 8., 6725.
FAU - Berek, Krisztina
AU  - Berek K
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szegedi Tudomanyegyetem, 
      Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert Klinikai Kozpont Szeged, 
      Semmelweis u. 8., 6725.
FAU - Kalapos, Anita
AU  - Kalapos A
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szegedi Tudomanyegyetem, 
      Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert Klinikai Kozpont Szeged, 
      Semmelweis u. 8., 6725.
FAU - Hartyanszky, Istvan
AU  - Hartyanszky I
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szivsebeszeti Osztaly, 
      Szegedi Tudomanyegyetem, Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert 
      Klinikai Kozpont Szeged.
FAU - Bogats, Gabor
AU  - Bogats G
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szivsebeszeti Osztaly, 
      Szegedi Tudomanyegyetem, Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert 
      Klinikai Kozpont Szeged.
FAU - Forster, Tamas
AU  - Forster T
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szegedi Tudomanyegyetem, 
      Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert Klinikai Kozpont Szeged, 
      Semmelweis u. 8., 6725.
FAU - Nemes, Attila
AU  - Nemes A
AD  - II. Belgyogyaszati Klinika es Kardiologiai Kozpont, Szegedi Tudomanyegyetem, 
      Altalanos Orvostudomanyi Kar, Szent-Gyorgyi Albert Klinikai Kozpont Szeged, 
      Semmelweis u. 8., 6725.
LA  - hun
PT  - Comparative Study
PT  - Journal Article
TT  - Az N-terminalis pro-B natriureticus peptid jelentosege a felnott koru 
      congenitalis szivbetegek gondozasaban - Eredmenyek a CSONGRAD Regiszterbol.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Defects, Congenital/*blood/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - *Quality of Life
MH  - Risk Factors
OTO - NOTNLM
OT  - NT-proBNP
OT  - adult congenital heart disease
OT  - felnott congenitalis szivbetegseg
OT  - heart failure
OT  - szivelegtelenseg
EDAT- 2018/01/23 06:00
MHDA- 2018/04/03 06:00
CRDT- 2018/01/23 06:00
PHST- 2018/01/23 06:00 [entrez]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
AID - 10.1556/650.2018.30942 [doi]
PST - ppublish
SO  - Orv Hetil. 2018 Jan;159(4):141-148. doi: 10.1556/650.2018.30942.