PMID- 29353543
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20220321
IS  - 1552-6844 (Electronic)
IS  - 1545-9683 (Linking)
VI  - 32
IP  - 2
DP  - 2018 Feb
TI  - Tai Chi Improves Cognition and Plasma BDNF in Older Adults With Mild Cognitive 
      Impairment: A Randomized Controlled Trial.
PG  - 142-149
LID - 10.1177/1545968317753682 [doi]
AB  - BACKGROUND: Effects of Tai Chi (TC) on specific cognitive function and mechanisms 
      by which TC may improve cognition in older adults with amnestic mild cognitive 
      impairment (a-MCI) remain unknown. OBJECTIVE: To examine the effects of TC on 
      cognitive functions and plasma biomarkers (brain-derived neurotrophic factor 
      [BDNF], tumor necrosis factor-alpha [TNF-alpha], and interleukin-10 [IL-10]) in a-MCI. 
      METHODS: A total of 66 older adults with a-MCI (mean age = 67.9 years) were 
      randomized to either a TC (n = 33) or a control group (n = 33). Participants in 
      the TC group learned TC with a certified instructor and then practiced at home 
      for 50 min/session, 3 times/wk for 6 months. The control group received 
      educational material that covered information related to cognition. The primary 
      outcome was cognitive performance, including Logical Memory (LM) delayed recall, 
      Block Design, Digit Span, and Trail Making Test B minus A (TMT B-A). The 
      secondary outcomes were plasma biomarkers, including BDNF, TNF-alpha, and IL-10. 
      RESULTS: At the end of the trial, performance on the LM and TMT B-A was 
      significantly better in the TC group compared with the control group after 
      adjusting for age, gender, and education ( P < .05). Plasma BDNF level was 
      significantly increased for the TC group, whereas the other outcome measures were 
      similar between the 2 groups after adjusting for age and gender ( P < .05). 
      CONCLUSIONS: TC training significantly improved memory and the mental switching 
      component of executive function in older adults with a-MCI, possibly via an 
      upregulation of BDNF.
FAU - Sungkarat, Somporn
AU  - Sungkarat S
AD  - 1 Chiang Mai University, Thailand.
FAU - Boripuntakul, Sirinun
AU  - Boripuntakul S
AD  - 1 Chiang Mai University, Thailand.
FAU - Kumfu, Sirinart
AU  - Kumfu S
AD  - 1 Chiang Mai University, Thailand.
FAU - Lord, Stephen R
AU  - Lord SR
AD  - 2 University of New South Wales, NSW, Australia.
FAU - Chattipakorn, Nipon
AU  - Chattipakorn N
AD  - 1 Chiang Mai University, Thailand.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180120
PL  - United States
TA  - Neurorehabil Neural Repair
JT  - Neurorehabilitation and neural repair
JID - 100892086
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/*physiology
MH  - Cognitive Dysfunction/blood/psychology/*rehabilitation
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Interleukin-10/blood
MH  - Male
MH  - Mental Recall/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - *Tai Ji
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - BDNF
OT  - Tai Chi
OT  - cognition
OT  - inflammatory markers
OT  - mild cognitive impairment
EDAT- 2018/01/23 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/01/23 06:00
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/01/23 06:00 [entrez]
AID - 10.1177/1545968317753682 [doi]
PST - ppublish
SO  - Neurorehabil Neural Repair. 2018 Feb;32(2):142-149. doi: 
      10.1177/1545968317753682. Epub 2018 Jan 20.