PMID- 29354360
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2190-572X (Print)
IS  - 2190-5738 (Electronic)
IS  - 2190-5738 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jan
TI  - Human leukocyte antigen (HLA-F) polymorphism is associated with chronic HBV 
      infection.
PG  - 49
LID - 10.1007/s13205-017-1079-9 [doi]
LID - 49
AB  - Human leukocyte antigen (HLA)-F has been involved in immune regulation of 
      infectious diseases. However, the role of HLA-F polymorphisms in hepatitis B 
      infection outcomes remains unclear. Here, we aimed to determine HLA-F 
      polymorphism implication in chronic HBV. Genotype analysis was performed for 
      three single nucleotide polymorphisms (SNPs) of HLA-F and one SNP of HLA-E using 
      PCR-SSP, in 252 Tunisian patients with chronic HBV infection stratified according 
      to their HBV DNA levels (140 patients with low HBV DNA levels < 2000 IU/mL and 
      112 patients with high HBV DNA levels >/= 2000 IU/mL) and 240 healthy controls 
      (CTRL). The three HLA-F SNPs (HLA-F*01:02, -F*01:03 and -F*01:04) have the same 
      allelic and genotypic frequencies in patients and in CTRL. We reported a low 
      HLA-F*01:02 and F*01:04 allelic frequencies in the Tunisian population; however, 
      high HLA-F*01:03 allele frequencies were observed (17%). A significant 
      association was found between the HLA-F*01:03 allele and decreased level of HBV 
      DNA (P = 0.02 OR 0.56, 95% CI 0.35-0.92). No significant differences were 
      observed in haplotype distribution between patients and CTRL. A significant 
      association of HLA-F*01:03 with the level of HBV DNA suggests an important role 
      of HLA-F in HBV replication control.
FAU - Laaribi, Ahmed Baligh
AU  - Laaribi AB
AD  - 1Laboratory of Microorganisms and Active Biomolecules LR03ES03, Sciences Faculty 
      of Tunis, Universite de Tunis El Manar, 2092 Tunis, Tunisia. ISNI: 
      0000000122959819. GRID: grid.12574.35
AD  - 2Laboratory of Microbiology-Immunology, UR12SP34, University Hospital Farhat 
      Hached, Sousse, Tunisia. GRID: grid.412791.8
AD  - Science Faculty of Bizerte, University of Cartage, Tunis, Tunisia.
FAU - Hannachi, Naila
AU  - Hannachi N
AD  - 2Laboratory of Microbiology-Immunology, UR12SP34, University Hospital Farhat 
      Hached, Sousse, Tunisia. GRID: grid.412791.8
FAU - Ben Yahia, Hamza
AU  - Ben Yahia H
AD  - 1Laboratory of Microorganisms and Active Biomolecules LR03ES03, Sciences Faculty 
      of Tunis, Universite de Tunis El Manar, 2092 Tunis, Tunisia. ISNI: 
      0000000122959819. GRID: grid.12574.35
FAU - Marzouk, Manal
AU  - Marzouk M
AD  - 2Laboratory of Microbiology-Immunology, UR12SP34, University Hospital Farhat 
      Hached, Sousse, Tunisia. GRID: grid.412791.8
FAU - Mehri, Asma
AU  - Mehri A
AD  - 2Laboratory of Microbiology-Immunology, UR12SP34, University Hospital Farhat 
      Hached, Sousse, Tunisia. GRID: grid.412791.8
AD  - Science Faculty of Bizerte, University of Cartage, Tunis, Tunisia.
FAU - Belhadj, Manel
AU  - Belhadj M
AD  - 2Laboratory of Microbiology-Immunology, UR12SP34, University Hospital Farhat 
      Hached, Sousse, Tunisia. GRID: grid.412791.8
FAU - Yacoub, Salwa
AU  - Yacoub S
AD  - 6Regional Center of Blood Transfusion, University Hospital Farhat Hached, Sousse, 
      Tunisia. GRID: grid.412791.8
FAU - Letaief, Amel
AU  - Letaief A
AD  - 4Department of Internal Medicine and Infectious Diseases, University Hospital 
      Farhat Hached, Sousse, Tunisia. GRID: grid.412791.8
FAU - Ouzari, Hadda-Imene
AU  - Ouzari HI
AD  - 1Laboratory of Microorganisms and Active Biomolecules LR03ES03, Sciences Faculty 
      of Tunis, Universite de Tunis El Manar, 2092 Tunis, Tunisia. ISNI: 
      0000000122959819. GRID: grid.12574.35
FAU - Boudabous, Abdellatif
AU  - Boudabous A
AD  - 1Laboratory of Microorganisms and Active Biomolecules LR03ES03, Sciences Faculty 
      of Tunis, Universite de Tunis El Manar, 2092 Tunis, Tunisia. ISNI: 
      0000000122959819. GRID: grid.12574.35
FAU - Boukadida, Jalel
AU  - Boukadida J
AD  - 2Laboratory of Microbiology-Immunology, UR12SP34, University Hospital Farhat 
      Hached, Sousse, Tunisia. GRID: grid.412791.8
FAU - Rizzo, Roberta
AU  - Rizzo R
AD  - 5Section Microbiology, Department of Experimental and Diagnostic Medicine, 
      University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: 
      grid.8484.0
FAU - Zidi, Ines
AU  - Zidi I
AD  - 1Laboratory of Microorganisms and Active Biomolecules LR03ES03, Sciences Faculty 
      of Tunis, Universite de Tunis El Manar, 2092 Tunis, Tunisia. ISNI: 
      0000000122959819. GRID: grid.12574.35
LA  - eng
PT  - Journal Article
DEP - 20180103
PL  - Germany
TA  - 3 Biotech
JT  - 3 Biotech
JID - 101565857
PMC - PMC5752667
OTO - NOTNLM
OT  - Chronic hepatitis
OT  - Fibrosis
OT  - Hepatitis B virus
OT  - Human leukocyte antigen-F
OT  - Single nucleotide polymorphism
COIS- Compliance with ethical standardsThe authors declare that there are no conflicts 
      of interests.
EDAT- 2018/01/23 06:00
MHDA- 2018/01/23 06:01
PMCR- 2019/01/01
CRDT- 2018/01/23 06:00
PHST- 2017/05/28 00:00 [received]
PHST- 2017/12/28 00:00 [accepted]
PHST- 2018/01/23 06:00 [entrez]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/01/23 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 1079 [pii]
AID - 10.1007/s13205-017-1079-9 [doi]
PST - ppublish
SO  - 3 Biotech. 2018 Jan;8(1):49. doi: 10.1007/s13205-017-1079-9. Epub 2018 Jan 3.