PMID- 29354685
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2373-8065 (Print)
IS  - 2373-8065 (Electronic)
IS  - 2373-8065 (Linking)
VI  - 4
DP  - 2018
TI  - Inflammatory gene expression signatures in idiopathic intracranial hypertension: 
      possible implications in microgravity-induced ICP elevation.
PG  - 1
LID - 10.1038/s41526-017-0036-6 [doi]
LID - 1
AB  - The visual impairment and intracranial pressure (VIIP) syndrome is a 
      neuro-ophthalmologic condition described in astronauts returning from long 
      duration space missions. Idiopathic intracranial hypertension (IIH), also known 
      as pseudotumor cerebri, is characterized by a chronic elevation of intracranial 
      pressure (ICP) in the absence of an intracranial mass lesion. Because VIIP and 
      IIH share some neurologic and ophthalmologic manifestations, the latter might be 
      used as a model to study some of the processes underlying VIIP. This work 
      constitutes a preliminary investigation of the molecular pathways associated with 
      the elevation of ICP in IIH. Gene expression signatures were obtained from 
      exosomes collected from CSF and plasma in patients with possible signs of IIH. 
      The gene expression targets focused on inflammatory genes and miRNAs. The results 
      suggest that inflammatory cytokine-driven processes and immune cell migration are 
      activated when ICP is elevated in IIH patients, either as a cause or effect of 
      the ICP increase. Several miRNAs appear to be involved in this response, among 
      which miR-9 and miR-16 are upregulated in CSF and plasma of higher ICP subjects. 
      This study provides evidence in support of neurophysiological alterations and 
      neuro-immunomodulation in this condition. If similar changes are seen in 
      astronauts manifesting with the VIIP syndrome, an underlying pathophysiological 
      basis may be discovered.
FAU - Zanello, Susana B
AU  - Zanello SB
AD  - 1KBRwyle, NASA Johnson Space Center, Houston, TX USA. ISNI: 0000 0004 0613 2864. 
      GRID: grid.419085.1
FAU - Tadigotla, Vasisht
AU  - Tadigotla V
AD  - 2Exosome Diagnostics, Cambridge, MA USA. GRID: grid.486907.4
FAU - Hurley, James
AU  - Hurley J
AD  - 2Exosome Diagnostics, Cambridge, MA USA. GRID: grid.486907.4
FAU - Skog, Johan
AU  - Skog J
AD  - 2Exosome Diagnostics, Cambridge, MA USA. GRID: grid.486907.4
FAU - Stevens, Brian
AU  - Stevens B
AD  - 3Baylor College of Medicine, Houston, TX USA. ISNI: 0000 0001 2160 926X. GRID: 
      grid.39382.33
FAU - Calvillo, Eusebia
AU  - Calvillo E
AD  - 3Baylor College of Medicine, Houston, TX USA. ISNI: 0000 0001 2160 926X. GRID: 
      grid.39382.33
FAU - Bershad, Eric
AU  - Bershad E
AD  - 3Baylor College of Medicine, Houston, TX USA. ISNI: 0000 0001 2160 926X. GRID: 
      grid.39382.33
LA  - eng
PT  - Journal Article
DEP - 20180111
PL  - United States
TA  - NPJ Microgravity
JT  - NPJ microgravity
JID - 101703605
PMC - PMC5764966
COIS- Dr Zanello is the recipient of the NASA award funding this study, as well as 
      other research support from the agency. Dr Tadigotla is employed by Exosome 
      Diagnostics, Inc. and holds stock options from Exosome Diagnostics. Dr James 
      Hurley is employed by Exosome Diagnostics, Inc. and holds stock options from 
      Exosome Diagnostics. Dr Skog is Chief Scientific Officer at Exosome Diagnostics, 
      Inc. and holds stock options from Exosome Diagnostics. Mr Brian Stevens and Ms 
      Eusebia Calvillo report no disclosures. Dr Bershad performs neurology clinical 
      practice, and conducts several research projects funded by NASA and the NSBRI 
      (National Space Biomedical Research Institute)
EDAT- 2018/01/23 06:00
MHDA- 2018/01/23 06:01
PMCR- 2018/01/11
CRDT- 2018/01/23 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/01/23 06:00 [entrez]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/01/23 06:01 [medline]
PHST- 2018/01/11 00:00 [pmc-release]
AID - 36 [pii]
AID - 10.1038/s41526-017-0036-6 [doi]
PST - epublish
SO  - NPJ Microgravity. 2018 Jan 11;4:1. doi: 10.1038/s41526-017-0036-6. eCollection 
      2018.