PMID- 29355381
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20200207
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 66
IP  - Suppl 4
DP  - 2017 Dec 30
TI  - Detection of microembolic signals in the common carotid artery using Doppler 
      sonography in the porcine model of acute heart failure treated by veno-arterial 
      extracorporeal membrane oxygenation.
PG  - S529-S536
AB  - Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a method used for 
      the treatment most severe cases of decompensated heart failure. The purpose of 
      this study was to evaluate the risk of the formation of microembolisms during 
      VA-ECMO-based therapy. Heart failure was induced with simultaneous detection of 
      microembolisms and the measurement of blood flow rate in the common carotid 
      artery (CCA) without VA-ECMO (0 l/min) and at the VA-ECMO blood flow rate of 1, 
      2, 3 and 4 l/min. If embolisms for VA-ECMO 0 l/min and the individual regimes for 
      VA-ECMO 1, 2, 3, 4 l/min are compared, a higher VA-ECMO flow rate is accompanied 
      by a higher number of microembolisms. The final microembolism value at 16 min was 
      for the VA-ECMO flow rate of 0 l/min 0.0 (0, 1), VA-ECMO l/min 7.5 (4, 19), 
      VA-ECMO 2 l/min 12.5 (4, 26), VA-ECMO 3 l/min, 21.0 (18, 57) and VA-ECMO 4 l/min, 
      27.5 (21, 64). Such a comparison is statistically significant if VA-ECMO 0 vs. 4 
      l/min p<0.0001, 0 vs. 3 l/min p<0.01 and 1 vs. 4 l/min p<0.01 are compared. The 
      results confirm that high VA-ECMO flow rates pose a risk with regards to the 
      formation of a significantly higher number of microemboli in the blood 
      circulation and that an increase in blood flow rates in the CCA corresponds to 
      changes in the VA-ECMO flow rates.
FAU - Janak, D
AU  - Janak D
AD  - Department of Physiology, First Faculty of Medicine, Charles University, Prague, 
      Czech Republic. janakdavid@seznam.cz.
FAU - Hala, P
AU  - Hala P
FAU - Mlcek, M
AU  - Mlcek M
FAU - Popkova, M
AU  - Popkova M
FAU - Lacko, S
AU  - Lacko S
FAU - Kudlicka, J
AU  - Kudlicka J
FAU - Kittnar, O
AU  - Kittnar O
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Blood Flow Velocity/physiology
MH  - Carotid Artery, Common/*diagnostic imaging/physiopathology
MH  - *Disease Models, Animal
MH  - Embolism/*diagnostic imaging/physiopathology
MH  - Extracorporeal Membrane Oxygenation/*adverse effects/trends
MH  - Female
MH  - Heart Failure/*diagnostic imaging/physiopathology/therapy
MH  - Microcirculation/physiology
MH  - Swine
MH  - Ultrasonography, Doppler/*methods/trends
EDAT- 2018/01/23 06:00
MHDA- 2018/08/14 06:00
CRDT- 2018/01/23 06:00
PHST- 2018/01/23 06:00 [entrez]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
AID - 933806 [pii]
AID - 10.33549/physiolres.933806 [doi]
PST - ppublish
SO  - Physiol Res. 2017 Dec 30;66(Suppl 4):S529-S536. doi: 10.33549/physiolres.933806.