PMID- 29355659
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 419
DP  - 2018 Apr 10
TI  - Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of 
      colorectal cancer through regulating chaperone mediated autophagy degradation of 
      p21(Cip1/WAF1).
PG  - 116-127
LID - S0304-3835(18)30067-3 [pii]
LID - 10.1016/j.canlet.2018.01.045 [doi]
AB  - Chaperone-mediated autophagy (CMA) characterized by the selective degradation of 
      target proteins has been linked with tumorigenesis in recent years. Here, we 
      explored the function of sorting nexin 10 (SNX10), a protein involved in 
      maintaining endosome/lysosome homeostasis, in mediating CMA activity and its 
      impact on the progression of mouse inflammation-driven colorectal cancer. Our 
      results revealed that SNX10 deficiency increased the activation of CMA by 
      preventing the degradation of lysosomal LAMP-2A. In SNX10 KO cells, we disclosed 
      that p21(Cip1/WAF1), a master effector in various tumor suppressor pathways, is a 
      substrate of CMA, and decrease of p21(Cip1/WAF1) caused by SNX10-mediated CMA 
      activation contributes to HCT116 cell proliferation and survival. Moreover, we 
      found that SNX10 KO promoted tumorigenesis in the mouse colorectum which could be 
      restored by SNX10 over-expression. Furthermore, SNX10 was remarkably 
      down-regulated in human CRC tissues which showed the increased activity of CMA 
      and decreased expression of p21(Cip1/WAF1). These findings suggest that SNX10 
      acts as a tumor suppressor in the mouse colorectum and drives 
      inflammation-associated colorectal cancer by a chaperone-mediated autophagy 
      mechanism.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zhang, Sulin
AU  - Zhang S
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Hu, Bin
AU  - Hu B
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - You, Yan
AU  - You Y
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Yang, Zhiwen
AU  - Yang Z
AD  - Department of Pharmacy, Songjiang Hospital Affiliated Shanghai First People's 
      Hospital, Shanghai Jiao Tong University, Shanghai, China.
FAU - Liu, Lixin
AU  - Liu L
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Tang, Huanhuan
AU  - Tang H
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Bao, Weilian
AU  - Bao W
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Guan, Yunyun
AU  - Guan Y
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Shen, Xiaoyan
AU  - Shen X
AD  - Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 
      China. Electronic address: shxiaoy@fudan.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Molecular Chaperones)
RN  - 0 (SNX10 protein, human)
RN  - 0 (Sorting Nexins)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Animals
MH  - *Autophagy
MH  - Carcinogenesis/genetics/*metabolism
MH  - Cell Proliferation/genetics
MH  - Cell Survival/genetics
MH  - Colorectal Neoplasms/genetics/*metabolism/pathology
MH  - Cyclin-Dependent Kinase Inhibitor p21/genetics/*metabolism
MH  - Disease Progression
MH  - HCT116 Cells
MH  - Humans
MH  - Mice, Knockout
MH  - Molecular Chaperones/genetics/metabolism
MH  - RNA Interference
MH  - Sorting Nexins/genetics/*metabolism
MH  - Tumor Suppressor Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - Chaperone-mediated autophagy
OT  - Colorectal cancer
OT  - SNX10
OT  - p21(Cip1/WAF1)
EDAT- 2018/01/23 06:00
MHDA- 2019/01/29 06:00
CRDT- 2018/01/23 06:00
PHST- 2017/09/13 00:00 [received]
PHST- 2017/12/05 00:00 [revised]
PHST- 2018/01/14 00:00 [accepted]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/01/23 06:00 [entrez]
AID - S0304-3835(18)30067-3 [pii]
AID - 10.1016/j.canlet.2018.01.045 [doi]
PST - ppublish
SO  - Cancer Lett. 2018 Apr 10;419:116-127. doi: 10.1016/j.canlet.2018.01.045.