PMID- 29355727
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 230
DP  - 2018 Apr 1
TI  - One-year follow-up of a randomized controlled trial of sertraline and cognitive 
      behavior group therapy in depressed primary care patients (MIND study).
PG  - 15-21
LID - S0165-0327(17)30943-6 [pii]
LID - 10.1016/j.jad.2017.12.084 [doi]
AB  - BACKGROUND: The long-term course of symptoms in patients with mild-to-moderate 
      depression is not well understood. A 12-month-follow-up analysis was performed on 
      those participants from a randomized controlled 10-week trial (RCT, MIND-study), 
      who had received either treatment with an antidepressant (sertraline) or a 
      psychotherapeutic intervention (group cognitive-behavioral therapy (CBT)). 
      METHODS: The longitudinal interval follow-up evaluation (LIFE) was applied to 77 
      patients with mild-to moderate depression. The primary outcome was the number of 
      weeks in the one-year follow-up period spent completely recovered from all 
      depressive symptoms. Functional outcome was measured with the Global Assessment 
      of Functioning (GAF) scale. Further outcomes were relapse and remission rates 
      based on weekly psychiatric rating scales (PSR) and the number of weeks in the 
      follow-up period during which patients had a depressive disorder or subthreshold 
      symptoms of depression. RESULTS: Patients with acute treatment (10 weeks) with 
      SSRI and those with acute treatment with CBT (also 10 weeks) did not differ 
      significantly concerning the number of weeks in the follow-up period in which 
      they were completely recovered (primary outcome) (SSRI: 31.6 weeks (standard 
      deviation (SD): 23.7), CBT: 27.8 weeks (SD: 24.3)). Sertraline was superior to 
      CBT regarding GAF scores by trend (p = 0.06). LIMITATIONS: The generalizability 
      of the findings is limited by the moderate sample size and missing values (LIFE). 
      CONCLUSIONS: Sertraline and group CBT have similar anti-depressive effects in the 
      long-term course of mild-to-moderate depression. Regarding long-term global 
      functioning, sertraline seems to be slightly superior to CBT.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Mergl, Roland
AU  - Mergl R
AD  - Department of Psychiatry and Psychotherapy, University Hospital Leipzig, 
      Semmelweisstr. 10, D-04103 Leipzig, Germany.
FAU - Allgaier, Antje-Kathrin
AU  - Allgaier AK
AD  - Department of Clinical Psychology, University of the Federal Armed Forces Munich, 
      Werner-Heisenberg-Weg 39, D-85577 Neubiberg, Germany.
FAU - Hautzinger, Martin
AU  - Hautzinger M
AD  - Department of Psychology, Eberhard-Karls-University Tuebingen, Christophstr. 2, 
      D-72072 Tuebingen, Germany.
FAU - Coyne, James C
AU  - Coyne JC
AD  - Department of Health Psychology, UMCG, Groningen and University of Groningen, 
      Groningen, The Netherlands.
FAU - Hegerl, Ulrich
AU  - Hegerl U
AD  - Department of Psychiatry and Psychotherapy, University Hospital Leipzig, 
      Semmelweisstr. 10, D-04103 Leipzig, Germany. Electronic address: 
      Ulrich.Hegerl@medizin.uni-leipzig.de.
FAU - Henkel, Verena
AU  - Henkel V
AD  - Department of Psychiatry, Ludwig-Maximilians-University Munich, Nussbaumstr. 7, 
      D-80336 Munich, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT00226642
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180102
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Cognitive Behavioral Therapy/*methods
MH  - Depression/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Primary Health Care
MH  - Psychotherapy, Group/*methods
MH  - Sertraline/*therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical trial
OT  - Cognitive-behavioral therapy
OT  - Depression
OT  - Long-term effects
OT  - Primary care
OT  - Sertraline
EDAT- 2018/01/23 06:00
MHDA- 2018/09/05 06:00
CRDT- 2018/01/23 06:00
PHST- 2017/05/10 00:00 [received]
PHST- 2017/11/29 00:00 [revised]
PHST- 2017/12/31 00:00 [accepted]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2018/01/23 06:00 [entrez]
AID - S0165-0327(17)30943-6 [pii]
AID - 10.1016/j.jad.2017.12.084 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Apr 1;230:15-21. doi: 10.1016/j.jad.2017.12.084. Epub 2018 
      Jan 2.