PMID- 29356954
OWN - NLM
STAT- MEDLINE
DCOM- 20190404
LR  - 20221207
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 297
IP  - 3
DP  - 2018 Mar
TI  - Frequency distribution of HLA alleles and haplotypes in Uyghur women with 
      advanced squamous cell cervical cancer and relation to HPV status and clinical 
      outcome.
PG  - 757-766
LID - 10.1007/s00404-018-4662-3 [doi]
AB  - PURPOSE: This study aims to investigate the association of human leukocyte 
      antigen (HLA) alleles and haplotypes in Uyghur women with advanced squamous cell 
      cervical cancer (SCC). METHODS: A total of 131 Uyghur patients with advanced SCC 
      (IIb-IVa) and 91 healthy subjects from Xinjiang province were genotyped for HLA-I 
      and II genes using Polymerase Chain Reaction Sequence Based Typing. The different 
      frequencies of HLA alleles and haplotypes between patients and controls were 
      compared and the correlations were analyzed between HLA distribution and HPV 
      status and prognosis. RESULTS: (1) The frequencies of B*51:01, DRB1*07:01, 
      DQB1*02:01, A*01:01-C*06:02, A*01:01-DRB1*07:01, C*06:02-DQB1*02:01, 
      DRB1*07:01-DQB1*02:01 and C*06:02-DRB1*07:01-DQB1*02:01 in cancer group were 
      higher than control group whereas the frequencies of B*44:02, B*58:01, C*05:01, 
      DRB1*04:01, DRB1*12:01, DRB1*13:01, DQB1*02:02, DQB1*05:02, DRB1*03:01-DQB1*02:02 
      and DRB1*04:01-DQB1*03:02 in cancer group were lower than control group 
      (P < 0.05). (2) The frequencies of A*01:01-C*06:02, A*01:01-DRB1*07:01, 
      C*06:02-DQB1*02:01, DRB1*07:01-DQB1*02:01 and C*06:02-DRB1*07:01-DQB1*02:01 in 
      HPV positive group were lower than HPV negative group, differences of which were 
      statistically significant (P < 0.05). (3) B*44:02 and B*58:01 were associated 
      with reduced disease-specific survival (DSS) (P = 0.010 and 0.007). (4) 
      Multivariate Cox proportional hazard models revealed that age, International 
      Federation of Gynaecology and Obstetrics (FIGO) stage, tumor differentiation and 
      allele B*58:01 as independent predictors for DSS while FIGO stage and tumor 
      differentiation as independent factors for DFS. CONCLUSIONS: In the development 
      and progression of advanced SCC among Uyghur population, the HLA alleles and its 
      haplotypes play an important role. B*58:01 allele may act as an independent 
      predictor for DSS.
FAU - Alifu, Mayinuer
AU  - Alifu M
AD  - Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, 830000, Xinjiang, China.
FAU - Fan, Peiwen
AU  - Fan P
AD  - Key Laboratory of Cancer Immunotherapy and Radiotherapy, Chinese Academy of 
      Medical Sciences, Urumqi, 830000, Xinjiang, China.
FAU - Kuerban, Gulina
AU  - Kuerban G
AD  - Department of Gynecology, The Affiliated Tumor Hospital of Xinjiang Medical 
      University, Urumqi, 830000, Xinjiang, China.
FAU - Yao, Xuan
AU  - Yao X
AD  - MRC Human Immunology Unit, Weatherall Institute of MolecularMedicine, Oxford 
      University, Oxford, OX3 9DS, UK.
FAU - Peng, Yanchun
AU  - Peng Y
AD  - MRC Human Immunology Unit, Weatherall Institute of MolecularMedicine, Oxford 
      University, Oxford, OX3 9DS, UK.
FAU - Dong, Tao
AU  - Dong T
AD  - Nuffield Department of Medicine, CAMS Oxford Center for Translational Immunology, 
      Chinese Academy of Medical Science Oxford Institute, Oxford University, Oxford, 
      OX3 9DS, UK. tao.dong@imm.ox.ac.uk.
AD  - MRC Human Immunology Unit, Weatherall Institute of MolecularMedicine, Oxford 
      University, Oxford, OX3 9DS, UK. tao.dong@imm.ox.ac.uk.
FAU - Wang, Ruozheng
AU  - Wang R
AUID- ORCID: 0000-0002-0524-1212
AD  - Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, 830000, Xinjiang, China. wrz8526@vip.163.com.
AD  - Key Laboratory of Cancer Immunotherapy and Radiotherapy, Chinese Academy of 
      Medical Sciences, Urumqi, 830000, Xinjiang, China. wrz8526@vip.163.com.
LA  - eng
GR  - 2012DFA31560/International Science and Technology Cooperation Project of 
      China/International
GR  - U1603282/Regional joint fund of the National Natural Science Foundation of 
      China/International
GR  - MR/L018942/1/MRC_/Medical Research Council/United Kingdom
GR  - G0600520/MRC_/Medical Research Council/United Kingdom
GR  - G1001046/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180122
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People/*ethnology/*genetics
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Epithelial Cells
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Uterine Cervical Neoplasms/epidemiology/*genetics/prevention & control
OTO - NOTNLM
OT  - Clinical outcome
OT  - Haplotype
OT  - Human leukocyte antigen (HLA)
OT  - Squamous cell cervical cancer (SCC)
OT  - Uyghur
EDAT- 2018/01/23 06:00
MHDA- 2019/04/05 06:00
CRDT- 2018/01/23 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2018/01/09 00:00 [accepted]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2019/04/05 06:00 [medline]
PHST- 2018/01/23 06:00 [entrez]
AID - 10.1007/s00404-018-4662-3 [pii]
AID - 10.1007/s00404-018-4662-3 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2018 Mar;297(3):757-766. doi: 10.1007/s00404-018-4662-3. 
      Epub 2018 Jan 22.