PMID- 29357007
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20190419
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 26
IP  - 3
DP  - 2018 Jun
TI  - Oral prednisolone versus non-steroidal anti-inflammatory drugs in the treatment 
      of acute gout: a meta-analysis of randomized controlled trials.
PG  - 717-723
LID - 10.1007/s10787-018-0442-8 [doi]
AB  - OBJECTIVES: To evaluate the efficacy and safety of oral prednisolone in the 
      treatment of acute gout compared with non-steroidal anti-inflammatory drugs 
      (NSAIDs). METHODS: A comprehensive search of databases in both Chinese and 
      English was performed. Data from the selected studies were extracted and analyzed 
      independently by two authors. RESULTS: Three double-blind, randomized, controlled 
      trials were included in the final analysis, with a total of 584 patients. 
      Regarding the efficacy, oral prednisolone (30-35 mg/day) was comparable with 
      NSAIDs (naproxen at 500 mg/day or indomethacin at 50-100 mg/day) on the pain 
      relief scale, both in activity (difference in means 0.259, 95% CI - 1.532 to 
      2.050, P = 0.777) and at rest (difference in means - 0.502, 95% CI - 4.961 to 
      3.956, P = 0.825) during the first 2-6 h. During the following 4 to 6 days, 
      prednisolone acted with comparable efficacy either in activity (difference in 
      means - 0.552, 95% CI - 1.364 to 0.260, P = 0.183) or at rest (difference in 
      means - 0.164, 95% CI - 0.463 to 0.134, P = 0.281). Regarding safety, 
      prednisolone did not increase the total adverse events (AEs) (risk ratios [RR] 
      0.765, 95% CI 0.473 to 1.238, P = 0.275) and reduced the withdrawal rate because 
      of the AEs (RR 0.127, 95% CI 0.021-0.763, P = 0.024). Prednisolone decreased the 
      risks of several AEs (including indigestion: RR 0.544, 95% CI 0.311-0.952, 
      P = 0.033; nausea: RR 0.296, 95% CI 0.136-0.647, P = 0.002; and vomiting: RR 
      0.155, 95% CI 0.033-0.722, P = 0.018) but increased the risk of skin rashes (RR 
      4.049, 95% CI 1.241-13.158, P = 0.021). CONCLUSIONS: Oral prednisolone may be of 
      similar efficacy and a slightly safer strategy for treatment of active, acute 
      gout compared with NSAIDs. Further clinical studies are still warranted to 
      investigate its long-term efficacy and safety.
FAU - Yu, Jie
AU  - Yu J
AD  - College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen 
      Road 548, Hangzhou, 310053, Zhejiang, China.
FAU - Lu, Haimei
AU  - Lu H
AD  - College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen 
      Road 548, Hangzhou, 310053, Zhejiang, China.
FAU - Zhou, Jia
AU  - Zhou J
AD  - College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen 
      Road 548, Hangzhou, 310053, Zhejiang, China.
FAU - Xie, Zhijun
AU  - Xie Z
AD  - College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen 
      Road 548, Hangzhou, 310053, Zhejiang, China.
FAU - Wen, Chengping
AU  - Wen C
AD  - College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen 
      Road 548, Hangzhou, 310053, Zhejiang, China.
FAU - Xu, Zhenghao
AU  - Xu Z
AUID- ORCID: 0000-0003-0033-525X
AD  - College of Basic Medical Science, Zhejiang Chinese Medical University, Binwen 
      Road 548, Hangzhou, 310053, Zhejiang, China. xuzhenghao@zcmu.edu.cn.
LA  - eng
GR  - LQ16H270004/Zhejiang Provincial Natural Science Foundation of China/
GR  - 81603088/National Natural Science Foundation of China/
GR  - 81673623/National Natural Science Foundation of China/
GR  - LY16H280005/Zhejiang Provincial Natural Science Foundation/
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20180122
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
EIN - Inflammopharmacology. 2019 Feb;27(1):199. PMID: 30062630
MH  - Administration, Oral
MH  - Anti-Inflammatory Agents/administration & dosage
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
MH  - Gout/*diagnosis/*drug therapy/epidemiology
MH  - Humans
MH  - Pain Management/methods
MH  - Pain Measurement/drug effects/methods
MH  - Prednisolone/*administration & dosage
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acute gout
OT  - Meta-analysis
OT  - NSAIDs
OT  - Pain
OT  - Prednisolone
EDAT- 2018/01/23 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/01/23 06:00
PHST- 2017/12/20 00:00 [received]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2018/01/23 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/01/23 06:00 [entrez]
AID - 10.1007/s10787-018-0442-8 [pii]
AID - 10.1007/s10787-018-0442-8 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2018 Jun;26(3):717-723. doi: 10.1007/s10787-018-0442-8. 
      Epub 2018 Jan 22.