PMID- 29357295 OWN - NLM STAT- MEDLINE DCOM- 20190218 LR - 20190219 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 671 DP - 2018 Apr 3 TI - Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia. PG - 1-6 LID - S0304-3940(18)30039-9 [pii] LID - 10.1016/j.neulet.2018.01.033 [doi] AB - Alcohol use disorder (AUD) is a leading risk factor of disease burden in the world. It is also commonly comorbid with over 20% of schizophrenia patients. The brain-derived neurotrophic factor (BDNF) and dopamine D3 receptor (DRD3) have been implicated in alcohol drinking behaviour. Previous genetic studies of the BDNF and DRD3 genes produced mixed findings; however, only one study investigated two BDNF genetic markers with alcohol dependence in schizophrenia patients. We investigated 15 single-nucleotide polymorphisms (SNPs) in DRD3 and four SNPs in BDNF for possible association with alcohol abuse or dependence in schizophrenia patients of European ancestry (N = 195). The patients were assessed for the occurrence of alcohol abuse or alcohol dependence using the Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-I/P). We found the BDNF Val66Met to be associated with alcohol dependence (p = 0.004). We also found haplotypes across BDNF to be nominally associated with alcohol dependence. Analyses of DRD3 markers and haplotypes yielded mostly negative findings. Our findings support a role of the BDNF gene in alcohol dependence in schizophrenia patients. Larger samples are required to confirm our findings, particularly those of BDNF haplotypes. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Zai, Clement C AU - Zai CC AD - Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada. Electronic address: Clement.zai@camh.ca. FAU - Manchia, Mirko AU - Manchia M AD - Section of Psychiatry, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. FAU - Zai, Gwyneth C AU - Zai GC AD - Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada. FAU - Woo, Julia AU - Woo J AD - Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada. FAU - Tiwari, Arun K AU - Tiwari AK AD - Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada. FAU - de Luca, Vincenzo AU - de Luca V AD - Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. FAU - Kennedy, James L AU - Kennedy JL AD - Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address: Jim.kennedy@camh.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180131 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (DRD3 protein, human) RN - 0 (Receptors, Dopamine D3) SB - IM MH - Adult MH - Alcoholism/complications/*genetics MH - Alleles MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Female MH - Genetic Association Studies MH - *Genetic Predisposition to Disease MH - Genotype MH - Haplotypes MH - Humans MH - Male MH - Middle Aged MH - *Polymorphism, Single Nucleotide MH - Receptors, Dopamine D3/*genetics MH - Schizophrenia/complications/*genetics OTO - NOTNLM OT - Alcohol abuse OT - Alcohol dependence OT - Brain-derived neurotrophic factor (BDNF) OT - Dopamine D3 receptor (DRD3) OT - Genetics OT - Schizophrenia EDAT- 2018/01/23 06:00 MHDA- 2019/02/20 06:00 CRDT- 2018/01/23 06:00 PHST- 2017/11/09 00:00 [received] PHST- 2018/01/04 00:00 [revised] PHST- 2018/01/17 00:00 [accepted] PHST- 2018/01/23 06:00 [pubmed] PHST- 2019/02/20 06:00 [medline] PHST- 2018/01/23 06:00 [entrez] AID - S0304-3940(18)30039-9 [pii] AID - 10.1016/j.neulet.2018.01.033 [doi] PST - ppublish SO - Neurosci Lett. 2018 Apr 3;671:1-6. doi: 10.1016/j.neulet.2018.01.033. Epub 2018 Jan 31.