PMID- 29358416 OWN - NLM STAT- MEDLINE DCOM- 20180816 LR - 20190202 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 8 IP - 1 DP - 2018 Jan 21 TI - Retrospective analysis assessing the spatial and temporal distribution of paediatric acute respiratory tract infections in Ho Chi Minh City, Vietnam. PG - e016349 LID - 10.1136/bmjopen-2017-016349 [doi] LID - e016349 AB - BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution, temporal trends and climatic risk factors of paediatric ARIs in Vietnam. METHODS: Data from hospitalised paediatric (<16 years) patients with ARIs residing in Ho Chi Minh City (HCMC) between 2005 and 2010 were retrieved from the two main Children's Hospitals and the Hospital for Tropical Diseases in HCMC. Spatial mapping and time series analysis were performed after disaggregating data into upper respiratory tract infections (URIs) and lower respiratory tract infections (LRIs). RESULTS: Over the study period, there were 155 999 paediatric patients admitted with ARIs (33% of all hospital admissions). There were 68 120 URIs (14%) and 87 879 LRIs (19%). The most common diagnoses were acute pharyngitis (28% of all ARI), pneumonia (21%), bronchitis (18%) and bronchiolitis (16%). A significant increasing trend over time was found for both URIs (mean weekly incidence per 1000 population, I=3.12), incidence rate ratio for 1-week increase in time (RR 1.0, 95% CI 1.02 to 1.17) for URI and (I=4.02, RR 1.08 (95% CI 1.006 to 1.16)) for LRI. The weekly URI incidence peaked in May-June and was significantly associated with lags in weekly URI incidence and the average humidity, rainfall and water level. The weekly LRI incidence exhibited significant seasonality (P<0.0001), with an annual peak in September-October and was significantly associated with lags in weekly LRI incidence and lags in weekly average temperature, rainfall and water level. CONCLUSIONS: ARIs are a leading cause of childhood hospitalisation in HCMC, Vietnam. The incidence of ARIs was higher in the wet season and in specific HCMC districts. These results may guide health authorities in where and when to effectively allocate resources for the prevention and control of ARIs. CI - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. FAU - Ho, Nhan Thi AU - Ho NT AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Vietnam. AD - Pediatrics, Columbia UniversityMedical Center, New York, New York, United States. FAU - Thompson, Corinne AU - Thompson C AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Vietnam. AD - Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. AD - Infection Biology, The London School of Hygiene & Tropical Medicine, London, UK. FAU - Nhan, Le Nguyen Thanh AU - Nhan LNT AD - General medicine, Children's Hospital 1, Ho Chi Minh City, Vietnam. FAU - Van, Hoang Minh Tu AU - Van HMT AD - General medicine, Children's Hospital 2, Ho Chi Minh City, Vietnam. FAU - Dung, Nguyen Thanh AU - Dung NT AD - General planning, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. FAU - Tran My, Phuc AU - Tran My P AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Vietnam. FAU - Quang, Vo Minh AU - Quang VM AD - General planning, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. FAU - Minh, Ngo Ngoc Quang AU - Minh NNQ AD - General medicine, Children's Hospital 1, Ho Chi Minh City, Vietnam. FAU - Tuan, Tran Anh AU - Tuan TA AD - General medicine, Children's Hospital 1, Ho Chi Minh City, Vietnam. FAU - Hung, Nguyen Thanh AU - Hung NT AD - General medicine, Children's Hospital 1, Ho Chi Minh City, Vietnam. FAU - Tuan, Ha Manh AU - Tuan HM AD - General medicine, Children's Hospital 2, Ho Chi Minh City, Vietnam. FAU - Vinh Chau, Nguyen Van AU - Vinh Chau NV AD - General planning, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. FAU - Wolbers, Marcel AU - Wolbers M AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Vietnam. AD - Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. FAU - Thwaites, Guy E AU - Thwaites GE AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Vietnam. AD - Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. FAU - Choisy, Marc AU - Choisy M AD - Institute of Research and Development, Ho Chi Minh City, Vietnam. FAU - Baker, Stephen AU - Baker S AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Vietnam. AD - Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. AD - Department of Medicine, University of Cambridge, Cambridge, UK. LA - eng GR - Wellcome Trust/United Kingdom GR - WT1093824/Wellcome Trust/United Kingdom GR - 100087/Z/12/Z/Wellcome Trust/United Kingdom PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20180121 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Acute Disease MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Hospitalization/*statistics & numerical data MH - Hospitals, Pediatric MH - Humans MH - Incidence MH - Infant MH - Infant, Newborn MH - Male MH - Respiratory Tract Infections/*epidemiology MH - Retrospective Studies MH - Risk Factors MH - *Seasons MH - Spatio-Temporal Analysis MH - Vietnam/epidemiology MH - *Weather PMC - PMC5780701 OTO - NOTNLM OT - acute respiratory infections OT - lower respiratory infections OT - pediatrics OT - spatial distribution OT - temporal patterns OT - upper respiratory infections COIS- Competing interests: None declared. EDAT- 2018/01/24 06:00 MHDA- 2018/08/17 06:00 PMCR- 2018/01/21 CRDT- 2018/01/24 06:00 PHST- 2018/01/24 06:00 [entrez] PHST- 2018/01/24 06:00 [pubmed] PHST- 2018/08/17 06:00 [medline] PHST- 2018/01/21 00:00 [pmc-release] AID - bmjopen-2017-016349 [pii] AID - 10.1136/bmjopen-2017-016349 [doi] PST - epublish SO - BMJ Open. 2018 Jan 21;8(1):e016349. doi: 10.1136/bmjopen-2017-016349.