PMID- 2935964
OWN - NLM
STAT- MEDLINE
DCOM- 19860226
LR  - 20041117
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 54
IP  - 3
DP  - 1985 Oct 30
TI  - Diversity of glycoprotein deficiencies in Glanzmann's thrombasthenia.
PG  - 626-9
AB  - The platelet proteins of 9 thrombasthenic patients from 7 families were analysed 
      by high resolution two-dimensional gel electrophoresis (HR-2DE) and crossed 
      immunoelectrophoresis (CIE). In 7 patients both glycoproteins (GPs) IIb and IIIa 
      were absent or reduced to roughly the same extent. In two related patients only a 
      trace of GP IIb-IIIa complex was detected in CIE, but HR-2DE revealed a 
      glycopeptide in the position of GP IIIa in an amount comparable to type II 
      thrombasthenia. This GP IIIa-like component was neither recognized normally by 
      anti-GP IIb-IIIa antibodies nor labeled by surface iodination. In 
      unreduced-reduced two-dimensional gel electrophoresis two components were 
      observed in the region of GP IIIa. The assumption of a structural variant of GP 
      IIIa in the two related patients is discussed.
FAU - Meyer, M
AU  - Meyer M
FAU - Herrmann, F H
AU  - Herrmann FH
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Platelet Membrane Glycoproteins)
SB  - IM
MH  - Blood Platelet Disorders/*blood
MH  - Blood Platelets/*analysis
MH  - Electrophoresis, Polyacrylamide Gel/methods
MH  - Glycoproteins/*analysis/genetics
MH  - Humans
MH  - Membrane Proteins/*analysis/blood/genetics
MH  - Oxidation-Reduction
MH  - Platelet Membrane Glycoproteins
MH  - Thrombasthenia/*blood/genetics
EDAT- 1985/10/30 00:00
MHDA- 1985/10/30 00:01
CRDT- 1985/10/30 00:00
PHST- 1985/10/30 00:00 [pubmed]
PHST- 1985/10/30 00:01 [medline]
PHST- 1985/10/30 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1985 Oct 30;54(3):626-9.