PMID- 29360438
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 149
DP  - 2018 Mar
TI  - Is there a role of H(2)S in mediating health span benefits of caloric 
      restriction?
PG  - 91-100
LID - S0006-2952(18)30030-3 [pii]
LID - 10.1016/j.bcp.2018.01.030 [doi]
AB  - Caloric restriction (CR) is a dietary regimen that aims to reduce the intake of 
      total calories while maintaining adequate supply of key nutrients so as to avoid 
      malnutrition. CR is one of only a small number of interventions that show 
      promising outcomes on health span and lifespan across different species. There is 
      growing interest in the development of compounds that might replicate CR-related 
      benefits without actually restricting food intake. Hydrogen sulfide (H(2)S) is 
      produced inside the bodies of many animals, including humans, by evolutionarily 
      conserved H(2)S synthesizing enzymes. Endogenous H(2)S is increasingly recognized 
      as an important gaseous signalling molecule involved in diverse cellular and 
      molecular processes. However, the specific role of H(2)S in diverse biological 
      processes remains to be elucidated and not all its biological effects are 
      beneficial. Nonetheless, recent evidence suggests that the biological functions 
      of H(2)S intersect with the network of evolutionarily conserved nutrient sensing 
      and stress response pathways that govern organismal responses to CR. Induction of 
      H(2)S synthesizing enzymes appears to be a conserved and essential feature of the 
      CR response in evolutionarily distant organisms, including nematodes and mice. 
      Here we review the evidence for a role of H(2)S in CR and lifespan modulation. 
      H(2)S releasing drugs, capable of controlled delivery of exogenous H(2)S, are 
      currently in clinical development. These findings suggest such H(2)S releasing 
      drugs as a promising novel avenue for the development of CR mimetic compounds.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Ng, Li Theng
AU  - Ng LT
AD  - Department of Pharmacology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore; Neurobiology Programme, Life Sciences Institute, 
      National University of Singapore, Singapore; Yale-NUS College, Science Division, 
      Singapore.
FAU - Gruber, Jan
AU  - Gruber J
AD  - Department of Biochemistry, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore; Yale-NUS College, Science Division, Singapore. 
      Electronic address: gruber@yale-nus.edu.sg.
FAU - Moore, Philip Keith
AU  - Moore PK
AD  - Department of Pharmacology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore; Neurobiology Programme, Life Sciences Institute, 
      National University of Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180131
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Gasotransmitters)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Energy Intake
MH  - Gasotransmitters/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Hydrogen Sulfide/*metabolism
MH  - Longevity/*physiology
OTO - NOTNLM
OT  - Ageing
OT  - Caloric restriction
OT  - Health span
OT  - Hydrogen sulfide
OT  - Lifespan
EDAT- 2018/01/24 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/01/24 06:00
PHST- 2017/11/03 00:00 [received]
PHST- 2018/01/17 00:00 [accepted]
PHST- 2018/01/24 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/01/24 06:00 [entrez]
AID - S0006-2952(18)30030-3 [pii]
AID - 10.1016/j.bcp.2018.01.030 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2018 Mar;149:91-100. doi: 10.1016/j.bcp.2018.01.030. Epub 2018 
      Jan 31.