PMID- 29361739
OWN - NLM
STAT- MEDLINE
DCOM- 20180803
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Jan 21
TI  - Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus 
      Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis.
LID - 10.3390/ijms19010317 [doi]
LID - 317
AB  - Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder of unknown 
      etiology, which is characterized by inflammation in the synovium and joint 
      damage. Although the pathogenesis of RA remains to be determined, a combination 
      of environmental (e.g., viral infections) and genetic factors influence disease 
      onset. Especially genetic factors play a vital role in the onset of disease, as 
      the heritability of RA is 50-60%, with the human leukocyte antigen (HLA) alleles 
      accounting for at least 30% of the overall genetic risk. Some HLA-DR alleles 
      encode a conserved sequence of amino acids, referred to as the shared epitope 
      (SE) structure. By analyzing the structure of a HLA-DR molecule in complex with 
      Epstein-Barr virus (EBV), the SE motif is suggested to play a vital role in the 
      interaction of MHC II with the viral glycoprotein (gp) 42, an essential entry 
      factor for EBV. EBV has been repeatedly linked to RA by several lines of evidence 
      and, based on several findings, we suggest that EBV is able to induce the onset 
      of RA in predisposed SE-positive individuals, by promoting entry of B-cells 
      through direct contact between SE and gp42 in the entry complex.
FAU - Trier, Nicole
AU  - Trier N
AD  - Department of Autoimmunology and Biomarkers, Statens Serum Institute, 
      Artillerivej 5, 2300 Copenhagen, Denmark. nhp@ssi.dk.
FAU - Izarzugaza, Jose
AU  - Izarzugaza J
AD  - Department of Bioinformatics, Technical University of Denmark, Anker Engelundsvej 
      1, 2800 Kongens Lyngby, Denmark. txema@bioinformatics.dtu.dk.
FAU - Chailyan, Anna
AU  - Chailyan A
AD  - Carlsberg Research Laboratory, J. C. Jacobsens Gade, 1799 Copenhagen, Denmark. 
      anna.chailyan@gmail.com.
FAU - Marcatili, Paolo
AU  - Marcatili P
AD  - Department of Bioinformatics, Technical University of Denmark, Anker Engelundsvej 
      1, 2800 Kongens Lyngby, Denmark. pamar@bioinformatics.dtu.dk.
FAU - Houen, Gunnar
AU  - Houen G
AD  - Department of Autoimmunology and Biomarkers, Statens Serum Institute, 
      Artillerivej 5, 2300 Copenhagen, Denmark. gh@ssi.dk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180121
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - *Amino Acid Motifs
MH  - Animals
MH  - Arthritis, Rheumatoid/*etiology/*immunology
MH  - Disease Susceptibility
MH  - Epitopes/*chemistry/*immunology
MH  - Epstein-Barr Virus Infections/*complications/*immunology
MH  - Herpesvirus 4, Human/*immunology
MH  - Histocompatibility Antigens Class II/chemistry/genetics/*immunology
MH  - Humans
MH  - Protein Binding
MH  - Risk Factors
PMC - PMC5796260
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - glycoprotein 42
OT  - rheumatoid arthritis
OT  - shared epitope
COIS- The authors declare no conflict of interest.
EDAT- 2018/01/25 06:00
MHDA- 2018/08/04 06:00
PMCR- 2018/01/01
CRDT- 2018/01/25 06:00
PHST- 2017/12/30 00:00 [received]
PHST- 2018/01/15 00:00 [revised]
PHST- 2018/01/17 00:00 [accepted]
PHST- 2018/01/25 06:00 [entrez]
PHST- 2018/01/25 06:00 [pubmed]
PHST- 2018/08/04 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ijms19010317 [pii]
AID - ijms-19-00317 [pii]
AID - 10.3390/ijms19010317 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Jan 21;19(1):317. doi: 10.3390/ijms19010317.