PMID- 29363305
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 66
IP  - 6
DP  - 2018 Feb 14
TI  - Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia 
      jasminoides Ellis Based on Mass Spectrometry Technique.
PG  - 1591-1599
LID - 10.1021/acs.jafc.7b06082 [doi]
AB  - Modern studies have indicated Gardenia jasminoides Ellis (G. jasminoides) showed 
      positive effect in treating type 2 diabetes mellitus (T2DM). In this study, 60 
      streptozotocin-induced T2DM rats were divided into four groups: type 2 diabetes 
      control group, geniposide-treated group, total iridoid glycosides-treated group, 
      and crude extraction of gardenlae fructus-treated group. The other ten healthy 
      rats were the healthy control group. During 12 weeks of treatment, rat's feces 
      samples were collected for the metabolomics study based on mass spectrometry 
      technique. On the basis of the fecal metabolomics method, 19 potential biomarkers 
      were screened and their relative intensities in each group were compared. The 
      results revealed G. jasminoides mainly regulated dysfunctions in phenylalanine 
      metabolism, tryptophan metabolism, and secondary bile acid biosynthesis pathways 
      induced by diabetes. The current study provides new insight for metabonomics 
      methodology toward T2DM, and the results show that feces can preferably reflect 
      the liver and intestines disorders.
FAU - Zhou, Yuan
AU  - Zhou Y
AD  - School of Pharmaceutical Sciences, Jilin University , Changchun 130012, China.
AD  - Key Laboratory of Magnetic Resonance in Biological Systems, National Center for 
      Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and 
      Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese 
      Academy of Sciences , Wuhan 430071, China.
FAU - Men, Lihui
AU  - Men L
AD  - School of Pharmaceutical Sciences, Jilin University , Changchun 130012, China.
FAU - Pi, Zifeng
AU  - Pi Z
AD  - National Center for Mass Spectrometry in Changchun & Jilin Province Key 
      Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun 
      Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, 
      China.
FAU - Wei, Mengying
AU  - Wei M
AD  - School of Pharmaceutical Sciences, Jilin University , Changchun 130012, China.
FAU - Song, Fengrui
AU  - Song F
AUID- ORCID: 0000-0001-7338-8139
AD  - National Center for Mass Spectrometry in Changchun & Jilin Province Key 
      Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun 
      Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, 
      China.
FAU - Zhao, Chunfang
AU  - Zhao C
AD  - School of Pharmaceutical Sciences, Jilin University , Changchun 130012, China.
FAU - Liu, Zhiqiang
AU  - Liu Z
AD  - National Center for Mass Spectrometry in Changchun & Jilin Province Key 
      Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun 
      Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, 
      China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180206
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*diet therapy/metabolism
MH  - Feces/*chemistry
MH  - Fruit/metabolism
MH  - Gardenia/*metabolism
MH  - Humans
MH  - Male
MH  - Mass Spectrometry/*methods
MH  - Metabolomics/*methods
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - G. jasminoides
OT  - UPLC-Q-TOF-MS
OT  - fecal metabolomics
OT  - type 2 diabetes
EDAT- 2018/01/25 06:00
MHDA- 2018/03/13 06:00
CRDT- 2018/01/25 06:00
PHST- 2018/01/25 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2018/01/25 06:00 [entrez]
AID - 10.1021/acs.jafc.7b06082 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2018 Feb 14;66(6):1591-1599. doi: 10.1021/acs.jafc.7b06082. 
      Epub 2018 Feb 6.