PMID- 29365036
OWN - NLM
STAT- MEDLINE
DCOM- 20191108
LR  - 20191108
IS  - 1941-7225 (Electronic)
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 31
IP  - 5
DP  - 2018 Apr 13
TI  - Real World Home Blood Pressure Variability in Over 56,000 Individuals With Nearly 
      17 Million Measurements.
PG  - 566-573
LID - 10.1093/ajh/hpx221 [doi]
AB  - BACKGROUND: Using the data from 56,365 individuals, from 185 countries, and a 
      Nokia Health Wireless blood pressure (BP) monitor, we investigated real-world 
      characteristics of BP variability (BPV). METHODS: All included individuals 
      self-measured and uploaded their BP using Bluetooth at least 20 times over a 
      period of >/=1 month at a frequency and duration of their choosing. In total, 
      16,904,844 BP measurements were analyzed, with a median of 146 measurements per 
      person (interquartile range [IQR] 73-321) over a median of 14 months (IQR 7-31). 
      SD, coefficient of variation, maximum BP, and maximum minus minimum BP difference 
      were all calculated as measures of BPV. RESULTS: BPV showed a distinct pattern, 
      influenced by season of year, day of week, and time of day. BPV index was higher 
      in females compared with males (P < 0.001) and increased with age (P < 0.001). 
      Compared to the weekend, the weekday BPV index was significantly higher, and this 
      finding was more prominent in females (P = 0.001). In multivariate analysis, BPV 
      index were significantly associated with age, gender, geographic location, and 
      mean BP values. CONCLUSION: Using the largest BP data set we are aware of, with 
      the benefits and limitations of real-world measurement, we could show the pattern 
      of BPV and provide reference values that may be helpful in understanding the 
      nature of BPV as self-measurement at home becomes more common, and help guide 
      individualized management.
FAU - Kim, Kwang-Il
AU  - Kim KI
AD  - Scripps Translational Science Institute, La Jolla, California, USA.
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seongnam, Korea.
FAU - Nikzad, Nima
AU  - Nikzad N
AD  - Scripps Translational Science Institute, La Jolla, California, USA.
FAU - Quer, Giorgio
AU  - Quer G
AD  - Scripps Translational Science Institute, La Jolla, California, USA.
FAU - Wineinger, Nathan E
AU  - Wineinger NE
AD  - Scripps Translational Science Institute, La Jolla, California, USA.
FAU - Vegreville, Matthieu
AU  - Vegreville M
AD  - Nokia Health, Issy-les-Moulineaux, France.
FAU - Normand, Alexis
AU  - Normand A
AD  - Nokia Health, Issy-les-Moulineaux, France.
FAU - Schmidt, Nicolas
AU  - Schmidt N
AD  - Nokia Health-USA, Cambridge, Massachusetts, USA.
FAU - Topol, Eric J
AU  - Topol EJ
AD  - Scripps Translational Science Institute, La Jolla, California, USA.
AD  - Division of Cardiovascular Medicine, Scripps Health, San Diego, California, USA.
FAU - Steinhubl, Steven
AU  - Steinhubl S
AD  - Scripps Translational Science Institute, La Jolla, California, USA.
AD  - Division of Cardiovascular Medicine, Scripps Health, San Diego, California, USA.
LA  - eng
GR  - UL1 TR001114/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/*physiology
MH  - Blood Pressure Determination
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Seasons
PMC - PMC5905665
EDAT- 2018/01/25 06:00
MHDA- 2019/11/09 06:00
PMCR- 2018/12/23
CRDT- 2018/01/25 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2017/12/19 00:00 [accepted]
PHST- 2018/01/25 06:00 [pubmed]
PHST- 2019/11/09 06:00 [medline]
PHST- 2018/01/25 06:00 [entrez]
PHST- 2018/12/23 00:00 [pmc-release]
AID - 4773965 [pii]
AID - hpx221 [pii]
AID - 10.1093/ajh/hpx221 [doi]
PST - ppublish
SO  - Am J Hypertens. 2018 Apr 13;31(5):566-573. doi: 10.1093/ajh/hpx221.