PMID- 29366645
OWN - NLM
STAT- MEDLINE
DCOM- 20190322
LR  - 20190322
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 81
IP  - 6
DP  - 2018 Jun
TI  - Serum nerve growth factor beta, brain- and glial-derived neurotrophic factor 
      levels and psychopathology in unmedicated patients with schizophrenia.
PG  - 577-581
LID - S1726-4901(17)30359-3 [pii]
LID - 10.1016/j.jcma.2017.11.010 [doi]
AB  - BACKGROUND: There is accumulating evidence that neurotrophic factors may be 
      involved in the pathophysiology of patients with schizophrenia. This study aimed 
      to explore the relationship between serum nerve growth factor beta (NGF-beta), 
      brain-derived neurotrophic factor (BDNF), and glial-derived neurotrophic factor 
      (GDNF) levels and psychopathology in unmedicated patients with schizophrenia. 
      METHODS: Serum NGF-beta, BDNF, and GDNF levels were determined using 
      enzyme-linked-immunosorbent assay (ELISA) in the serum of 30 unmedicated patients 
      with schizophrenia. Symptomatology was assessed with the expanded version of the 
      24-items brief psychiatric rating scale (BPRS-E), which was divided into four 
      conceptual domains: manic excitement/disorganization, depression/anxiety, 
      negative symptoms, and positive symptoms. Kolmogorov-Smirnov one sample test was 
      performed to test non-parametric variables. Spearman's correlation was performed 
      to examine the correlations between the cytokines of interest and 
      psychopathology. Benjamini-Hochberg procedure was applied for multiple 
      corrections. RESULTS: Serum GDNF levels correlated negatively with the BPRS-total 
      (r = -0.533, corrected p = 0.002) and BPRS-manic (r = -0.456, corrected 
      p = 0.011) subtests. BDNF levels showed a positive correlation with BPRS-total 
      (r = 0.480, corrected p = 0.007). In addition, NGF-beta did not associate with 
      psychopathology measured by BPRS scores. CONCLUSION: Neurotrophic factors play a 
      vital role in the regulation of neuroplasticity and neurogenesis in humans. This 
      study suggests that BDNF and GDNF may be contributing to the pathological 
      mechanisms involved in unmedicated patients with schizophrenia.
CI  - Copyright (c) 2018. Published by Elsevier Taiwan LLC.
FAU - Chu, Che-Sheng
AU  - Chu CS
AD  - Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 
      ROC; Center for Geriatric and Gerontology, Kaohsiung Veterans General Hospital, 
      Kaohsiung, Taiwan, ROC.
FAU - Chu, Chin-Liang
AU  - Chu CL
AD  - Rong Xin Mental Health Clinic, Kaohsiung, Taiwan, ROC.
FAU - Wu, Chih-Ching
AU  - Wu CC
AD  - Department of Medical Biotechnology and Laboratory Science, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan, ROC; Department of Otolaryngology-Head & 
      Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, ROC.
FAU - Lu, Ti
AU  - Lu T
AD  - Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 
      ROC. Electronic address: tlu@vghks.gov.tw.
LA  - eng
PT  - Journal Article
DEP - 20180201
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood/physiology
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/*blood/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*blood/physiology
MH  - Psychiatric Status Rating Scales
MH  - Psychopathology
MH  - Schizophrenia/blood/*etiology
OTO - NOTNLM
OT  - Cytokines
OT  - Neurotrophic factors
OT  - Psychopathology
OT  - Schizophrenia
EDAT- 2018/01/26 06:00
MHDA- 2019/03/23 06:00
CRDT- 2018/01/26 06:00
PHST- 2017/09/12 00:00 [received]
PHST- 2017/11/09 00:00 [revised]
PHST- 2017/11/10 00:00 [accepted]
PHST- 2018/01/26 06:00 [pubmed]
PHST- 2019/03/23 06:00 [medline]
PHST- 2018/01/26 06:00 [entrez]
AID - S1726-4901(17)30359-3 [pii]
AID - 10.1016/j.jcma.2017.11.010 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2018 Jun;81(6):577-581. doi: 10.1016/j.jcma.2017.11.010. Epub 
      2018 Feb 1.