PMID- 29368650
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 17
IP  - 1
DP  - 2018 Jan 24
TI  - Association of depression with evolution of heart failure in patients with type 2 
      diabetes mellitus.
PG  - 19
LID - 10.1186/s12933-018-0664-5 [doi]
LID - 19
AB  - BACKGROUND: Depression is a prevalent, independent predictor of mortality in 
      patients with heart failure (HF). Depression is also common in type 2 diabetes 
      mellitus (T2DM), which is itself an important risk factor for HF. However, 
      association of depression with incident HF in T2DM is undefined. The aim of the 
      present study was to evaluate the predictive value of depression in predicting 
      incident HF in a community-based cohort of asymptomatic patients with T2DM. 
      METHODS: We prospectively recruited 274 asymptomatic T2DM patients >/= 65 years 
      (age 71 +/- 4 year, 56% men) with preserved EF and no ischemic heart disease from a 
      community-based population. The Patient Health Questionnaire 9 (PHQ-9) was used 
      to detect depression, and LV dysfunction was sought with a comprehensive 
      echocardiogram, including LV hypertrophy (LVH) and subclinical diastolic function 
      (E/e'). Over a median follow-up of 1.5 years (range 0.5-3), 20 patients were lost 
      to follow-up and 254 individuals were followed for outcomes. RESULTS: At 
      baseline, depression was present in 9.5%, LVH was identified in 26% and reduced 
      E/e' in 11%. Over a median follow-up of 1.5 years, 37 of 245 patients developed 
      new-onset HF and 3 died, giving an event rate of 107/1000 person-years. In a 
      competing-risks regression analysis, depression (adjusted HR 2.54, 95% CI 
      1.18-5.46; p = 0.017) was associated with incident HF and had incremental 
      predictive power to clinical, biochemical and echocardiographic variables. 
      CONCLUSION: Depression is prevalent in asymptomatic elderly patients with T2DM, 
      and depression independently and incrementally predicts incident HF.
FAU - Wang, Ying
AU  - Wang Y
AD  - Menzies Institute for Medical Research, Baker Heart and Diabetes Institute, 
      Melbourne, Australia.
FAU - Yang, Hong
AU  - Yang H
AD  - Menzies Institute for Medical Research, Baker Heart and Diabetes Institute, 
      Melbourne, Australia.
FAU - Nolan, Mark
AU  - Nolan M
AD  - Menzies Institute for Medical Research, Baker Heart and Diabetes Institute, 
      Melbourne, Australia.
FAU - Burgess, John
AU  - Burgess J
AD  - Faculty of Health Sciences, Baker Heart and Diabetes Institute, Melbourne, 
      Australia.
FAU - Negishi, Kazuaki
AU  - Negishi K
AD  - Menzies Institute for Medical Research, Baker Heart and Diabetes Institute, 
      Melbourne, Australia.
FAU - Marwick, Thomas H
AU  - Marwick TH
AUID- ORCID: 0000-0001-9065-0899
AD  - Menzies Institute for Medical Research, Baker Heart and Diabetes Institute, 
      Melbourne, Australia. Tom.Marwick@bakeridi.edu.au.
AD  - Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, 
      Australia. Tom.Marwick@bakeridi.edu.au.
LA  - eng
GR  - Y14G-MART1/Diabetes Australia Research Trust/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180124
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Affect
MH  - Age Factors
MH  - Aged
MH  - Depression/diagnosis/*epidemiology/psychology
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Disease Progression
MH  - Female
MH  - Heart Failure/diagnostic imaging/*epidemiology/physiopathology
MH  - Humans
MH  - Hypertrophy, Left Ventricular/diagnostic imaging/*epidemiology/physiopathology
MH  - Incidence
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*epidemiology/physiopathology
MH  - Ventricular Function, Left
MH  - Victoria/epidemiology
PMC - PMC5781289
OTO - NOTNLM
OT  - Depression
OT  - Incident heart failure
OT  - Type 2 diabetes mellitus
EDAT- 2018/01/26 06:00
MHDA- 2019/01/29 06:00
PMCR- 2018/01/24
CRDT- 2018/01/26 06:00
PHST- 2017/11/30 00:00 [received]
PHST- 2018/01/16 00:00 [accepted]
PHST- 2018/01/26 06:00 [entrez]
PHST- 2018/01/26 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/01/24 00:00 [pmc-release]
AID - 10.1186/s12933-018-0664-5 [pii]
AID - 664 [pii]
AID - 10.1186/s12933-018-0664-5 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2018 Jan 24;17(1):19. doi: 10.1186/s12933-018-0664-5.