PMID- 29369669
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20200827
IS  - 1939-1846 (Electronic)
IS  - 0021-843X (Print)
IS  - 0021-843X (Linking)
VI  - 127
IP  - 1
DP  - 2018 Jan
TI  - Social motivation in schizophrenia: The impact of oxytocin on vigor in the 
      context of social and nonsocial reinforcement.
PG  - 116-128
LID - 10.1037/abn0000320 [doi]
AB  - Experiential negative symptoms-including diminished motivation-have a profound 
      impact on functional outcomes in schizophrenia. Animal research suggests that 
      abnormalities in dopaminergic regulation can negatively impact effort exertion, a 
      translational model that has been applied to individuals with schizophrenia. 
      Paradigms that assess effort-based decision making, for example, suggest less 
      likelihood of choosing high effort tasks that are high in probability of success, 
      and this preference varies with negative symptoms and impaired functioning. 
      Although asociality is another well-documented component of experiential negative 
      symptoms, it is unclear whether diminished motivation for monetary reward extends 
      to the social domain. To test this question, the authors designed the Social 
      Vigor Task (SVT)-a measure of effort exertion in the context of live social 
      encouragement. They further examined the effect of oxytocin, a neuropeptide 
      implicated in social behavior, on vigor. Forty-two individuals with schizophrenia 
      and 43 healthy controls completed the SVT twice: once after intranasal 
      administration of saline placebo and again after oxytocin. Both groups showed 
      similar increases in vigor in response to social encouragement, suggesting effort 
      in the social context is spared in schizophrenia. Group differences in the effect 
      of social encouragement on vigor varied by point-based reward rate and trial 
      length. Oxytocin did not increase vigor during social encouragement in either 
      group. Within the schizophrenia group, clinician-rated passive social withdrawal, 
      but not active social avoidance, was negatively associated with vigor. Results 
      suggest that people with schizophrenia show normative levels of effort in the 
      context of social encouragement; low approach motivation, however, relates to 
      lower effort. (PsycINFO Database Record
CI  - (c) 2018 APA, all rights reserved).
FAU - Fulford, Daniel
AU  - Fulford D
AD  - Departments of Occupational Therapy and Psychological & Brain Sciences, Boston 
      University.
FAU - Treadway, Michael
AU  - Treadway M
AD  - Department of Psychology, Emory University.
FAU - Woolley, Joshua
AU  - Woolley J
AD  - San Francisco Veterans Affairs Medical Center.
LA  - eng
GR  - IK2 CX000758/CX/CSRD VA/United States
PT  - Journal Article
PL  - United States
TA  - J Abnorm Psychol
JT  - Journal of abnormal psychology
JID - 0034461
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - *Motivation
MH  - Oxytocin/administration & dosage/*physiology
MH  - Reward
MH  - Schizophrenia/*physiopathology
MH  - *Schizophrenic Psychology
MH  - *Social Behavior
PMC - PMC7446385
MID - NIHMS1578797
EDAT- 2018/01/26 06:00
MHDA- 2019/01/10 06:00
PMCR- 2020/08/25
CRDT- 2018/01/26 06:00
PHST- 2018/01/26 06:00 [entrez]
PHST- 2018/01/26 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2020/08/25 00:00 [pmc-release]
AID - 2018-02683-005 [pii]
AID - 10.1037/abn0000320 [doi]
PST - ppublish
SO  - J Abnorm Psychol. 2018 Jan;127(1):116-128. doi: 10.1037/abn0000320.