PMID- 29370115
OWN - NLM
STAT- MEDLINE
DCOM- 20180801
LR  - 20181202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 2
DP  - 2018 Jan 25
TI  - Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced 
      Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of 
      Acetylcholinesterase.
LID - 10.3390/ijms19020363 [doi]
LID - 363
AB  - Though Oldenlandia diffusa Herba (ODH) has been known to exhibit anti-cancer and 
      anti-inflammatory effects, its anti-amnestic effect has never been reported so 
      far. The aim of this present study was to elucidate the anti-amnestic effect of 
      ODH. ODH pretreatment significantly reduced escape latency of scopolamine treated 
      Institute of Cancer Research (ICR) mice compared to untreated control groups in a 
      Morris water maze test. Similarly, the passive avoidance test showed that ODH 
      treatment recovered the scopolamine induced amnesia in the ICR mouse model. 
      Concentration of Ach in brains of ODH treated mice was increased compared to that 
      of scopolamine treated mice. In addition, activity of acetylcholinesterase (AChE) 
      was notably decreased by ODH. The protein expression of brain-derived 
      neurotrophic factor (BDNF) and phospho-cAMP response element-binding protein 
      (p-CREB) (Ser133) was increased in ODH pretreated group compared to control 
      group. Consistently, immunohistochemistry (IHC) revealed the elevated expression 
      of brain-derived neurotrophic factor (BDNF) and p-CREB in brains of ODH treated 
      mice compared to the control group. Overall, these findings suggest that ODH has 
      anti-amnestic potential via activation of BDNF and p-CREB and inhibition of AChE 
      in mice with scopolamine induced amnesia.
FAU - Lee, Jung Eun
AU  - Lee JE
AD  - Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. 
      jungeunlee@khu.ac.kr.
FAU - Song, Hyo-Sook
AU  - Song HS
AD  - Department of Science in Korean Medicine, College of Korean Medicine, Graduate 
      School, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. 
      shs331@khu.ac.kr.
FAU - Park, Moon Nyeo
AU  - Park MN
AD  - Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. mnpark@khu.ac.kr.
FAU - Kim, Sung-Hoon
AU  - Kim SH
AUID- ORCID: 0000-0003-2423-1973
AD  - Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. 
      sungkim7@khu.ac.kr.
FAU - Shim, Bum-Sang
AU  - Shim BS
AD  - Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. eshimbs@khu.ac.kr.
FAU - Kim, Bonglee
AU  - Kim B
AUID- ORCID: 0000-0002-8678-156X
AD  - Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. 
      bongleekim@khu.ac.kr.
AD  - Department of Science in Korean Medicine, College of Korean Medicine, Graduate 
      School, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea. 
      bongleekim@khu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180125
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
EIN - Int J Mol Sci. 2018 Mar 27;19(4):. PMID: 29584649
MH  - Acetylcholine/metabolism
MH  - Acetylcholinesterase/metabolism
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cholinergic Antagonists/toxicity
MH  - Cholinesterase Inhibitors/*pharmacology/therapeutic use
MH  - Cognitive Dysfunction/*drug therapy/etiology
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neuroprotective Agents/*pharmacology/therapeutic use
MH  - Oldenlandia/*chemistry
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Scopolamine/toxicity
PMC - PMC5855585
OTO - NOTNLM
OT  - Oldenlandia diffusa Herba
OT  - acetylcholinesterase
OT  - brain-derived neurotrophic factor
OT  - phospho-cAMP response element-binding protein
OT  - scopolamine
COIS- The authors declare no conflict of interest.
EDAT- 2018/01/26 06:00
MHDA- 2018/08/02 06:00
PMCR- 2018/02/01
CRDT- 2018/01/26 06:00
PHST- 2017/12/19 00:00 [received]
PHST- 2018/01/16 00:00 [revised]
PHST- 2018/01/25 00:00 [accepted]
PHST- 2018/01/26 06:00 [entrez]
PHST- 2018/01/26 06:00 [pubmed]
PHST- 2018/08/02 06:00 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - ijms19020363 [pii]
AID - ijms-19-00363 [pii]
AID - 10.3390/ijms19020363 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Jan 25;19(2):363. doi: 10.3390/ijms19020363.