PMID- 29370674
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2233-6834 (Print)
IS  - 2233-6842 (Electronic)
IS  - 2233-6834 (Linking)
VI  - 21
IP  - 4
DP  - 2017 Dec 31
TI  - Effects of acute voluntary loaded wheel running on BDNF expression in the rat 
      hippocampus.
PG  - 52-57
LID - 10.20463/jenb.2017.0034 [doi]
AB  - PURPOSE: Voluntary loaded wheel running involves the use of a load during a 
      voluntary running activity. A muscle-strength or power-type activity performed at 
      a relatively high intensity and a short duration may cause fewer apparent 
      metabolic adaptations but may still elicit muscle fiber hypertrophy. This study 
      aimed to determine the effects of acute voluntary wheel running with an 
      additional load on brain-derived neurotrophic factor (BDNF) expression in the rat 
      hippocampus. METHODS: Ten-week old male Wistar rats were assigned randomly to a 
      (1) sedentary (Control) group; (2) voluntary exercise with no load (No-load) 
      group; or (3) voluntary exercise with an additional load (Load) group for 1-week 
      (acute period). The expression of BDNF genes was quantified by real-time PCR. 
      RESULTS: The average distance levels were not significantly different in the 
      No-load and Load groups. However, the average work levels significantly increased 
      in the Load group. The relative soleus weights were greater in the No-load group. 
      Furthermore, loaded wheel running up-regulated the BDNF mRNA level compared with 
      that in the Control group. The BDNF mRNA levels showed a positive correlation 
      with workload levels (r=0.75), suggesting that the availability of multiple 
      workload levels contributes to the BDNF-related benefits of loaded wheel running 
      noted in this study. CONCLUSION: This novel approach yielded the first set of 
      findings showing that acute voluntary loaded wheel running, which causes muscular 
      adaptation, enhanced BDNF expression, suggesting a possible role of 
      high-intensity short-term exercise in hippocampal BDNF activity.
CI  - (c)2017 The Korean Society for Exercise Nutrition
FAU - Lee, Minchul
AU  - Lee M
FAU - Soya, Hideaki
AU  - Soya H
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Exerc Nutrition Biochem
JT  - Journal of exercise nutrition & biochemistry
JID - 101572566
PMC - PMC5772069
OTO - NOTNLM
OT  - voluntary loaded wheel running
EDAT- 2018/01/27 06:00
MHDA- 2018/01/27 06:01
PMCR- 2017/12/31
CRDT- 2018/01/27 06:00
PHST- 2017/11/28 00:00 [received]
PHST- 2017/12/28 00:00 [accepted]
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/01/27 06:01 [medline]
PHST- 2017/12/31 00:00 [pmc-release]
AID - JENB_2017_v21n4 [pii]
AID - JENB_2017_v21n4_52 [pii]
AID - 10.20463/jenb.2017.0034 [doi]
PST - ppublish
SO  - J Exerc Nutrition Biochem. 2017 Dec 31;21(4):52-57. doi: 10.20463/jenb.2017.0034.