PMID- 29370799
OWN - NLM
STAT- MEDLINE
DCOM- 20180815
LR  - 20181113
IS  - 1472-6793 (Electronic)
IS  - 1472-6793 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Jan 25
TI  - Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking 
      tissue-type plasminogen activator.
PG  - 2
LID - 10.1186/s12899-018-0036-0 [doi]
LID - 2
AB  - BACKGROUND: Circadian rhythms of physiology and behavior are driven by a 
      circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This 
      clock is synchronized to environmental day/night cycles by photic input, which is 
      dependent on the presence of mature brain-derived neurotrophic factor (BDNF) in 
      the SCN. Mature BDNF is produced by the enzyme plasmin, which is converted from 
      plasminogen by the enzyme tissue-type plasminogen activator (tPA). In this study, 
      we evaluate circadian function in mice lacking functional tPA. RESULTS: tPA(-/-) 
      mice have normal circadian periods, but show decreased nocturnal wheel-running 
      activity. This difference is eliminated or reversed on the second day of a 48-h 
      fast. Similarly, when placed on daily cycles of restricted food availability the 
      genotypic difference in total wheel-running activity disappears, and tPA(-/-) 
      mice show equivalent amounts of food anticipatory activity to wild type mice. 
      CONCLUSIONS: These data suggest that tPA regulates nocturnal wheel-running 
      activity, and that tPA differentially affects SCN-driven nocturnal activity 
      rhythms and activity driven by fasting or temporal food restriction.
FAU - Krizo, Jessica A
AU  - Krizo JA
AD  - Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA.
FAU - Moreland, Linley E
AU  - Moreland LE
AD  - Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA.
FAU - Rastogi, Ashutosh
AU  - Rastogi A
AD  - Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA.
FAU - Mou, Xiang
AU  - Mou X
AD  - Department of Molecular and Cellular Biology, Baylor College of Medicine, 
      Houston, TX, 77030, USA.
FAU - Prosser, Rebecca A
AU  - Prosser RA
AD  - Department of Biochemistry and Cellular and Molecular Biology, University of 
      Tennessee, Knoxville, TN, 37996, USA.
FAU - Mintz, Eric M
AU  - Mintz EM
AD  - Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA. 
      emintz@kent.edu.
LA  - eng
GR  - IOS-1021957/National Science Foundation/
PT  - Journal Article
DEP - 20180125
PL  - England
TA  - BMC Physiol
JT  - BMC physiology
JID - 101088687
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Circadian Clocks
MH  - *Circadian Rhythm
MH  - Eating
MH  - Fasting
MH  - Food Deprivation
MH  - *Locomotion
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity
MH  - Suprachiasmatic Nucleus/metabolism
MH  - Tissue Plasminogen Activator/genetics/*physiology
PMC - PMC5784530
OTO - NOTNLM
OT  - Circadian
OT  - Food anticipatory activity
OT  - Wheel-running
COIS- ETHICS APPROVAL: All animal use protocols in this study were approved by the Kent 
      State Institutional Animal Care and Use Committee and were performed in 
      accordance with the recommendations in the Guide for the Care and Use of 
      Laboratory Animals of the National Institutes of Health. CONSENT FOR PUBLICATION: 
      Not applicable. COMPETING INTERESTS: The authors declare that they have no 
      competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with 
      regard to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/01/27 06:00
MHDA- 2018/08/16 06:00
PMCR- 2018/01/25
CRDT- 2018/01/27 06:00
PHST- 2017/03/23 00:00 [received]
PHST- 2018/01/15 00:00 [accepted]
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/08/16 06:00 [medline]
PHST- 2018/01/25 00:00 [pmc-release]
AID - 10.1186/s12899-018-0036-0 [pii]
AID - 36 [pii]
AID - 10.1186/s12899-018-0036-0 [doi]
PST - epublish
SO  - BMC Physiol. 2018 Jan 25;18(1):2. doi: 10.1186/s12899-018-0036-0.