PMID- 29370975
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1464-3405 (Electronic)
IS  - 0960-894X (Linking)
VI  - 28
IP  - 4
DP  - 2018 Feb 15
TI  - Design and synthesis of novel senkyunolide analogues as neuroprotective agents.
PG  - 668-672
LID - S0960-894X(18)30028-3 [pii]
LID - 10.1016/j.bmcl.2018.01.018 [doi]
AB  - A class of senkyunolide analogues bearing benzofuranone fragment were designed, 
      synthesized and evaluated for their neuroprotective effect in models of oxygen 
      glucose deprivation (OGD) and oxidative stress. All tested compounds showed 
      neuroprotection profile based on the cell viability assay. In particular, 
      derivatives 1f-1i possessing furoxan-based nitric oxide releasing functionality 
      exhibited significant biological activities in OGD models. More importantly, 
      compound 1g containing short linker with furoxan displayed the most potent 
      neuroprotection at the concentration of 100 muM (cell survival up to 145.2%). 
      Besides, 1g also showed the middle level neuroprotective effect in model of 
      oxidative stress.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Fang, Yuanying
AU  - Fang Y
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China.
FAU - Wang, Rikang
AU  - Wang R
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China.
FAU - Wang, Qi
AU  - Wang Q
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China.
FAU - Sun, Yongbing
AU  - Sun Y
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China.
FAU - Xie, Saisai
AU  - Xie S
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China.
FAU - Yang, Zunhua
AU  - Yang Z
AD  - College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 
      330004, China. Electronic address: joshyyy@126.com.
FAU - Li, Min
AU  - Li M
AD  - College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 
      330004, China.
FAU - Jin, Yi
AU  - Jin Y
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China. Electronic address: yinghua616909@hotmail.com.
FAU - Yang, Shilin
AU  - Yang S
AD  - National Engineering Research Center for Manufacturing Technology of TCM Solid 
      Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180112
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Antioxidants)
RN  - 0 (Benzofurans)
RN  - 0 (Coumaric Acids)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nitric Oxide Donors)
RN  - 0 (Oxadiazoles)
RN  - 74QZK813SO (3-N-butyl-4,5-dihydrophthalide)
RN  - AVM951ZWST (ferulic acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemical synthesis/pharmacology
MH  - Benzofurans/chemical synthesis/*pharmacology
MH  - Cell Line
MH  - Coumaric Acids/pharmacology
MH  - Drug Design
MH  - Mice
MH  - Molecular Structure
MH  - Neuroprotective Agents/chemical synthesis/*pharmacology
MH  - Nitric Oxide Donors/chemical synthesis/*pharmacology
MH  - Oxadiazoles/chemical synthesis/*pharmacology
MH  - Oxidative Stress/drug effects
OTO - NOTNLM
OT  - Acute cerebral ischemia
OT  - Furoxan
OT  - Neuroprotective agents
OT  - Senkyunolide analogues
EDAT- 2018/01/27 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/01/27 06:00
PHST- 2017/11/22 00:00 [received]
PHST- 2018/01/07 00:00 [revised]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/01/27 06:00 [entrez]
AID - S0960-894X(18)30028-3 [pii]
AID - 10.1016/j.bmcl.2018.01.018 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2018 Feb 15;28(4):668-672. doi: 10.1016/j.bmcl.2018.01.018. 
      Epub 2018 Jan 12.