PMID- 29371754
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 0912-0009 (Print)
IS  - 1880-5086 (Electronic)
IS  - 0912-0009 (Linking)
VI  - 62
IP  - 1
DP  - 2018 Jan
TI  - Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 
      and MAPK signaling pathways in rats.
PG  - 56-62
LID - 10.3164/jcbn.17-40 [doi]
AB  - Previously, we showed that 0.5% quercetin simultaneously decreased serum 
      homocysteine and glutathione (GSH) levels in rats. The aim of the present study 
      was to investigate the effects of 0.5% quercetin on GSH metabolism, related 
      enzymes and signal pathways in rats. Rats were fed the control diet and 0.5% 
      quercetin-supplemented diet for 6 weeks. The results showed that quercetin 
      reduced serum and hepatic content of GSH and the ratio of GSH and oxidized 
      glutathione (GSSG), enhanced hepatic activity and mRNA expression of glutathione 
      S-transferase (GST), inhibited hepatic activity and mRNA expression of glutamate 
      cysteine ligase (GCL), and decreased hepatic glutathione reductase (GR) mRNA 
      expression. Levels of phosphorylated p38 and extracellular signal-regulated 
      kinase (ERK) 1/2 mitogen-activated protein kinases (MAPKs) increased, while that 
      of nuclear factor E2-like 2 (Nrf2) protein decreased after quercetin treatment. 
      However, no significant hepatotoxicity was noted. We concluded that quercetin 
      treatment altered hepatic GSH metabolism by modulating GSH metabolic enzyme 
      activities and mRNA expression in rats, and p38, ERK1/2 MAPKs, and Nrf2 were 
      involved in modulating GSH metabolism-related enzymes.
FAU - Gao, Weina
AU  - Gao W
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Pu, Lingling
AU  - Pu L
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Chen, Ming
AU  - Chen M
AD  - The People's Hospital of Lichuan, Jiangxi Province, 344600, P. R. China.
FAU - Wei, Jingyu
AU  - Wei J
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Xin, Zhonghao
AU  - Xin Z
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Wang, Yawen
AU  - Wang Y
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Yao, Zhanxin
AU  - Yao Z
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Shi, Tala
AU  - Shi T
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
FAU - Guo, Changjiang
AU  - Guo C
AD  - Tianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 
      300050, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - Japan
TA  - J Clin Biochem Nutr
JT  - Journal of clinical biochemistry and nutrition
JID - 8700907
PMC - PMC5773830
OTO - NOTNLM
OT  - MAPKs
OT  - Nrf2
OT  - glutamate cysteine ligase
OT  - glutathione
OT  - quercetin
COIS- No potential conflicts of interest were disclosed.
EDAT- 2018/01/27 06:00
MHDA- 2018/01/27 06:01
PMCR- 2018/01/01
CRDT- 2018/01/27 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/09/08 00:00 [accepted]
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/01/27 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - jcbn17-40 [pii]
AID - 10.3164/jcbn.17-40 [doi]
PST - ppublish
SO  - J Clin Biochem Nutr. 2018 Jan;62(1):56-62. doi: 10.3164/jcbn.17-40. Epub 2017 Dec 
      12.