PMID- 29372032 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220408 IS - 2008-3866 (Print) IS - 2008-3874 (Electronic) IS - 2008-3866 (Linking) VI - 21 IP - 1 DP - 2018 Jan TI - Protective effect of metformin on D-galactose-induced aging model in mice. PG - 19-25 LID - 10.22038/IJBMS.2017.24331.6071 [doi] AB - OBJECTIVES: Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. MATERIALS AND METHODS: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). RESULTS: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. CONCLUSION: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors. FAU - Fatemi, Iman AU - Fatemi I AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. AD - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. FAU - Khaluoi, Amin AU - Khaluoi A AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. FAU - Kaeidi, Ayat AU - Kaeidi A AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. AD - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. FAU - Shamsizadeh, Ali AU - Shamsizadeh A AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. AD - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. FAU - Heydari, Sara AU - Heydari S AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. FAU - Allahtavakoli, Mohammad Aa AU - Allahtavakoli MA AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. AD - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Basic Med Sci JT - Iranian journal of basic medical sciences JID - 101517966 PMC - PMC5776431 OTO - NOTNLM OT - Aging OT - D-galactose OT - Metformin OT - Mouse OT - Oxidative stress EDAT- 2018/01/27 06:00 MHDA- 2018/01/27 06:01 PMCR- 2018/01/01 CRDT- 2018/01/27 06:00 PHST- 2018/01/27 06:00 [entrez] PHST- 2018/01/27 06:00 [pubmed] PHST- 2018/01/27 06:01 [medline] PHST- 2018/01/01 00:00 [pmc-release] AID - IJBMS-21-19 [pii] AID - 10.22038/IJBMS.2017.24331.6071 [doi] PST - ppublish SO - Iran J Basic Med Sci. 2018 Jan;21(1):19-25. doi: 10.22038/IJBMS.2017.24331.6071.