PMID- 29372612
OWN - NLM
STAT- MEDLINE
DCOM- 20190118
LR  - 20210109
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 6
IP  - 2
DP  - 2018 Jan
TI  - Statins decrease leptin expression in human white adipocytes.
LID - 10.14814/phy2.13566 [doi]
LID - e13566
AB  - Statin use is associated with increased calorie intake and consequent weight 
      gain. It is speculated that statin-dependent improvements in lipid profile may 
      undermine the perceived need to follow lipid-lowering and other dietary 
      recommendations leading consequently to increased calorie intake. However, 
      increases in calorie intake in statin users may also be related to 
      statin-dependent decreases in satiety factors such as leptin, an 
      adipocyte-derived adipokine. The objective of our study was to examine the direct 
      effects of statins on leptin expression. Adipocytes are the main source of 
      circulating leptin. Therefore, we examined the effects of atorvastatin and 
      simvastatin on leptin expression in cultured human white adipocytes. We show that 
      treatment of white adipocytes with simvastatin and atorvastatin decreases leptin 
      mRNA expression (simvastatin: P = 0.008, atorvastatin: P = 0.03) and leptin 
      secretion (simvastatin: P = 0.0001, atorvastatin: P = 0.0001). Both simvastatin 
      and atorvastatin mediate decreases in leptin expression via 
      extracellular-signal-regulated kinases 1/2 and peroxisome proliferator-activated 
      receptor gamma pathways (simvastatin: P = 0.01, atorvastatin: P = 0.026). 
      Additionally, statin treatment also induced expected increases in adiponectin, 
      while decreasing monocyte chemoattractant protein 1 (MCP1) mRNA. Furthermore, 
      statins increased secretion of both total as well as high molecular weight 
      adiponectin while decreasing MCP1 secretion. To conclude, statins act directly on 
      human white adipocytes to regulate adipokine secretion and decrease leptin 
      expression. Leptin is an important satiety factor. Hence, statin-dependent 
      decreases in leptin may contribute, at least in part, to increases in food intake 
      in statin users.
CI  - (c) 2018 Mayo Foundation For Medical Education And Research. Physiological Reports 
      published by Wiley Periodicals, Inc. on behalf of the American Physiological 
      Society and The Physiological Society.
FAU - Singh, Prachi
AU  - Singh P
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Zhang, Yuebo
AU  - Zhang Y
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Sharma, Pragya
AU  - Sharma P
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Covassin, Naima
AU  - Covassin N
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Soucek, Filip
AU  - Soucek F
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
AD  - ICRC - Department of Cardiovascular Diseases, St. Anne's University Hospital, 
      Brno, Czech Republic.
FAU - Friedman, Paul A
AU  - Friedman PA
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Somers, Virend K
AU  - Somers VK
AD  - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
LA  - eng
GR  - R01 HL065176/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (LEP protein, human)
RN  - 0 (Leptin)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Adipocytes, White/*drug effects/metabolism
MH  - Adiponectin/biosynthesis
MH  - Atorvastatin/adverse effects
MH  - Cells, Cultured
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects
MH  - Leptin/*biosynthesis
MH  - Simvastatin/adverse effects
PMC - PMC5789723
OTO - NOTNLM
OT  - Leptin
OT  - satiety
OT  - statins
EDAT- 2018/01/27 06:00
MHDA- 2019/01/19 06:00
PMCR- 2018/01/26
CRDT- 2018/01/27 06:00
PHST- 2017/12/05 00:00 [received]
PHST- 2017/12/09 00:00 [accepted]
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2019/01/19 06:00 [medline]
PHST- 2018/01/26 00:00 [pmc-release]
AID - PHY213566 [pii]
AID - 10.14814/phy2.13566 [doi]
PST - ppublish
SO  - Physiol Rep. 2018 Jan;6(2):e13566. doi: 10.14814/phy2.13566.