PMID- 29372759
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181001
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 35
IP  - 11
DP  - 2017 Nov 8
TI  - [Determination of six allergenic coumarin compounds in children's toys using 
      hollow-fiber liquid-phase microextraction followed by ultra-performance liquid 
      chromatography-tandem mass spectrometry].
PG  - 1145-1151
LID - 10.3724/SP.J.1123.2017.08011 [doi]
AB  - A comprehensive analytical method was developed for the determination of six 
      allergenic coumarin compounds (coumarin, 7-methyl coumarin, 7-methoxycoumarin, 
      7-ethoxy-4-methyl coumarin, 4,6-dimethyl-8-tert-butyl coumarin and 
      hexahydrocoumarin) in children's toys based on hollow-fiber liquid-phase 
      microextraction (HF-LPME) followed by ultra-performance liquid 
      chromatography-tandem mass spectrometry (UPLC-MS/MS). HF-LPME was employed in 
      sample pretreatment with the following parameters:extraction solvent of 
      n-octanol, stirring rate of 700 r/min, extraction time of 50 min and amount of 
      sodium chloride of 0.7 g. After chromatographic separation on an ACQUITY UPLC BEH 
      Phenyl column (150 mmx2.1 mm, 1.7 mum), the target compounds were analyzed under 
      multiple reaction monitoring (MRM) mode in positive electrospray ionization mode. 
      The limits of quantification (LOQs) of the six allergenic coumarin compounds were 
      either 2 mug/kg (7-ethoxy-4-methyl coumarin and 4,6-dimethyl-8-tert-butyl 
      coumarin) or 10 mug/kg (coumarin, hexahydrocoumarin, 7-methyl coumarin and 
      7-methoxycoumarin). The average recoveries at different spiked levels ranged from 
      70.8% to 118.9% with relative standard deviations (RSDs) of 0.19%-16.34% (n=6). 
      The proposed method is accurate, sensitive, reliable, and can be applied for the 
      inspection and quality control of toy products.
FAU - Hu, Mingzhu
AU  - Hu M
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
FAU - Lian, Xianhui
AU  - Lian X
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
AD  - School of Life Science and Medicine, Dalian University of Technology, Panjin 
      124221, China.
FAU - Liu, Han
AU  - Liu H
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
FAU - Guo, Xiangyu
AU  - Guo X
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
FAU - Lu, Yueguang
AU  - Lu Y
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
AD  - School of Chemistry and Chemical Engineering, University of Chinese Academy of 
      Sciences, Beijing 101407, China.
FAU - Bai, Hua
AU  - Bai H
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
FAU - Xue, Hongyu
AU  - Xue H
AD  - School of Life Science and Medicine, Dalian University of Technology, Panjin 
      124221, China.
FAU - Ma, Qiang
AU  - Ma Q
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100176, China. 
      maqiang@caiq.gov.cn.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Allergens)
RN  - 0 (Coumarins)
RN  - 0 (Imidazoles)
RN  - 0 (Thiazoles)
RN  - 0 (coumarin 6)
RN  - 0 (coumarin 7)
SB  - IM
MH  - Allergens/*isolation & purification
MH  - Chromatography, High Pressure Liquid
MH  - Coumarins/*isolation & purification
MH  - Imidazoles
MH  - Liquid Phase Microextraction
MH  - *Play and Playthings
MH  - Tandem Mass Spectrometry
MH  - Thiazoles
OTO - NOTNLM
OT  - allergenic coumarin compounds
OT  - children's toys
OT  - hollow-fiber membrane
OT  - liquid-phase microextraction (LPME)
OT  - ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
EDAT- 2018/01/27 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/01/27 06:00
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.08011 [doi]
PST - ppublish
SO  - Se Pu. 2017 Nov 8;35(11):1145-1151. doi: 10.3724/SP.J.1123.2017.08011.