PMID- 29372770
OWN - NLM
STAT- MEDLINE
DCOM- 20181004
LR  - 20181004
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 35
IP  - 12
DP  - 2017 Dec 8
TI  - [Rapid screening of fipronil and its metabolites in egg and egg products by solid 
      phase extraction-liquid chromatography-quadrupole time-of-flight mass 
      spectrometry].
PG  - 1216-1223
LID - 10.3724/SP.J.1123.2017.09026 [doi]
AB  - A method for rapid screening of fipronil and its metabolites in egg and egg 
      products was developed by liquid chromatography coupled with quadrupole 
      time-of-flight mass spectrometry (LC-QTOF MS). The samples were extracted by 
      acid-acetonitrile, cleaned up by PRiME HLB SPE. The separation was performed on a 
      Poroshell 120 EC C18 column (150 mmx3 mm, 2.7 mum) with gradient elution using 
      water and acetonitrile as mobile phases. The target compounds were monitored 
      under negative ionization mode with electrospray ionization (ESI) source and two 
      databases of accurate mass and fragment ions were created. The matrix effects in 
      four kinds of egg and egg products were considered and the quantification was 
      carried out by internal standard method. The results demonstrated that the linear 
      ranges were from 0.1 to 5 mug/L with good correlation coefficients (r(2)>0.99). 
      The limits of detection (LODs, S/N>3) and limits of quantitation (LOQs, S/N>10) 
      were 0.2 mug/kg and 1 mug/kg, respectively. The recoveries of fipronil and its 
      metabolites in different matrixes spiked with 1, 2 and 5 mug/kg varied from 
      82.6%-98.1%, and the relative standard deviations (RSDs) were between 3.8%-9.9% 
      (n=6). The method can effectively correct the ionization suppression. It is 
      sensitive, accurate and suitable for the rapid screening of fipronil, fipronil 
      sulfide, fipronil sulfone and fipronil desulfinyl in egg, egg noodle, cake and 
      mayonnaise.
FAU - Guo, Dehua
AU  - Guo D
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Shi, Yiyin
AU  - Shi Y
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China. 
      shiyy@shciq.gov.cn.
FAU - Li, You
AU  - Li Y
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Yi, Xionghai
AU  - Yi X
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Deng, Xiaojun
AU  - Deng X
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Xiao, Wenqing
AU  - Xiao W
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Li, Xiao
AU  - Li X
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Liu, Han
AU  - Liu H
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Shen, Weijian
AU  - Shen W
AD  - Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Pyrazoles)
RN  - KE7T0T1PQ7 (fipronil sulfone)
RN  - QGH063955F (fipronil)
SB  - IM
MH  - Chromatography, Liquid
MH  - Eggs/*analysis
MH  - Food Analysis/*methods
MH  - Limit of Detection
MH  - Pyrazoles/*analysis
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - egg and egg products
OT  - fipronil and its metabolites
OT  - liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF MS)
OT  - screening
OT  - solid phase extraction (SPE)
EDAT- 2018/01/27 06:00
MHDA- 2018/10/05 06:00
CRDT- 2018/01/27 06:00
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/10/05 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.09026 [doi]
PST - ppublish
SO  - Se Pu. 2017 Dec 8;35(12):1216-1223. doi: 10.3724/SP.J.1123.2017.09026.