PMID- 29372776
OWN - NLM
STAT- MEDLINE
DCOM- 20181004
LR  - 20181004
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 35
IP  - 12
DP  - 2017 Dec 8
TI  - [Determination of 21 illegally added chemical drugs in health foods using ultra 
      performance liquid chromatography-tandem mass spectrometry coupled with 
      QuEChERS].
PG  - 1257-1265
LID - 10.3724/SP.J.1123.2017.09031 [doi]
AB  - A method for the simultaneous determination of 21 illegally added chemical drugs 
      in improving sleep and immunity health foods using ultra performance liquid 
      chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed. Oral liquid 
      and health wine samples were shaken with acetonitrile and 
      acetonitrile-water-formic acid (60:39:1, v/v/v), respectively, then purified by 
      QuEChERS method. The extracts were separated on an Acquity UPLC(TM) BEH C18 
      column (50 mmx2.1 mm, 1.7 mum) with gradient elution of acetonitrile and 2 mmol/L 
      ammonium acetate solution containing 0.1% (v/v) formic acid as mobile phases. The 
      electrospray ionization in positive ion mode was used for analysis in multiple 
      reaction monitoring (MRM) mode. The results showed that the target drugs had a 
      good linear relationship in the range of 1-100 mug/L with the correlation 
      coefficients (R(2)) >/= 0.992. The limits of detection (LODs) and limits of 
      quantification (LOQs) were 0.07-3.41 mug/kg and 0.22-11.36 mug/kg, respectively. 
      The average recoveries of the 21 chemical drugs in oral liquid and health wine 
      were in the range of 61.4%-116.5% and 67.4%-98.4% with the relative standard 
      deviations (RSDs) of 0.2%-13.4% and 0.2%-11.8%, respectively. The developed 
      method is sensitive and reliable. It has been successfully used for the detection 
      of illegally added chemical drugs in real samples.
FAU - Zheng, Jia
AU  - Zheng J
AD  - College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
AD  - Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 
      400016, China.
FAU - Xi, Cunxian
AU  - Xi C
AD  - Chongqing Entry-Exit Inspection and Quarantine Bureau Chongqing Engineering 
      Technology Research Center of Import and Export Food Safety, Chongqing 400020, 
      China.
FAU - Cao, Shurui
AU  - Cao S
AD  - Chongqing Entry-Exit Inspection and Quarantine Bureau Chongqing Engineering 
      Technology Research Center of Import and Export Food Safety, Chongqing 400020, 
      China.
FAU - Wang, Guomin
AU  - Wang G
AD  - Chongqing Entry-Exit Inspection and Quarantine Bureau Chongqing Engineering 
      Technology Research Center of Import and Export Food Safety, Chongqing 400020, 
      China.
FAU - Tang, Bobin
AU  - Tang B
AD  - Chongqing Entry-Exit Inspection and Quarantine Bureau Chongqing Engineering 
      Technology Research Center of Import and Export Food Safety, Chongqing 400020, 
      China.
FAU - Wang, Zhi
AU  - Wang Z
AD  - College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
AD  - Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 
      400016, China.
FAU - Mu, Zhaode
AU  - Mu Z
AD  - College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
AD  - Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 
      400016, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
SB  - IM
MH  - *Chromatography, High Pressure Liquid
MH  - Food Contamination/*analysis
MH  - Limit of Detection
MH  - *Tandem Mass Spectrometry
MH  - Wine/*analysis
OTO - NOTNLM
OT  - QuEChERS
OT  - chemical drugs
OT  - health foods
OT  - ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
EDAT- 2018/01/27 06:00
MHDA- 2018/10/05 06:00
CRDT- 2018/01/27 06:00
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/10/05 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.09031 [doi]
PST - ppublish
SO  - Se Pu. 2017 Dec 8;35(12):1257-1265. doi: 10.3724/SP.J.1123.2017.09031.