PMID- 29373070
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20180925
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 21
IP  - 3
DP  - 2018 Mar
TI  - Lipolysis-Stimulating Peptide from Soybean Protects Against High Fat Diet-Induced 
      Apoptosis in Skeletal Muscles.
PG  - 225-232
LID - 10.1089/jmf.2017.3941 [doi]
AB  - Obesity is generally associated with low-grade chronic inflammation that involves 
      the recruitment of macrophages and other inflammation factors to the adipocytes 
      of obese individuals. Tumor necrosis factor-alpha (TNF-alpha), a cytokine associated 
      with systemic inflammation, is elevated in conditions of obesity. TNF-alpha is an 
      important factor that plays an important role in skeletal muscle wasting. 
      Apoptosis of myonuclei contributes to the loss of muscle mass and therefore plays 
      an important role in skeletal muscle atrophy. In mouse models that were fed a 
      high fat diet (HFD), a lipolysis-stimulating peptide-VHVV (purified from 
      hydrolysate resulting from flavourzyme treatment of soy protein) was found to 
      reduce HFD-related apoptotic effects in mice skeletal muscle and potentially 
      control atrophy. HFD fed mice had heavier body weight than those fed with normal 
      chow, and VHVV administration restricted lipid accumulation in muscle tissues of 
      mice fed with HFD but increased nutrient uptake. Moreover, specific 
      concentrations of VHVV regulated TNF-alpha expression that was elevated by HFD, 
      suppressed apoptosis-related proteins and regulated the proteins of lipid 
      metabolism.
FAU - Marthandam Asokan, Shibu
AU  - Marthandam Asokan S
AD  - 1 Department for Management of Science and Technology Development, Ton Duc Thang 
      University , Ho Chi Minh City, Vietnam .
AD  - 2 Faculty of Applied Sciences, Ton Duc Thang University , Ho Chi Minh City, 
      Vietnam .
FAU - Hung, Tsu-Han
AU  - Hung TH
AD  - 3 Department of Hospitality Management, College of Agriculture, Tunghai 
      University , Taichung, Taiwan, Republic of China .
FAU - Chiang, Wen-Dee
AU  - Chiang WD
AD  - 4 Department of Food Science, College of Agriculture, Tunghai University , 
      Taichung, Taiwan, Republic of China .
FAU - Lin, Wan-Teng
AU  - Lin WT
AD  - 3 Department of Hospitality Management, College of Agriculture, Tunghai 
      University , Taichung, Taiwan, Republic of China .
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180126
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (Soybean Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Apoptosis/*drug effects
MH  - Apoptosis Regulatory Proteins/antagonists & inhibitors/metabolism
MH  - Biomarkers/metabolism
MH  - Body Weight/drug effects
MH  - Diet, High-Fat/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Energy Intake/drug effects
MH  - Injections, Intraperitoneal
MH  - Lipolysis/*drug effects
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Muscle, Skeletal/*drug effects/immunology/metabolism/pathology
MH  - Muscular Atrophy/etiology/metabolism/pathology/*prevention & control
MH  - Obesity/chemically induced/etiology/immunology/physiopathology
MH  - Oligopeptides/administration & dosage/adverse effects/*therapeutic use
MH  - Peptide Fragments/administration & dosage/adverse effects/therapeutic use
MH  - Random Allocation
MH  - Soybean Proteins/administration & dosage/adverse effects/therapeutic use
MH  - Specific Pathogen-Free Organisms
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - NAFLD
OT  - apoptosis
OT  - high fat diet
OT  - lipolysis-stimulating peptides
OT  - obesity
EDAT- 2018/01/27 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/01/27 06:00
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/01/27 06:00 [entrez]
AID - 10.1089/jmf.2017.3941 [doi]
PST - ppublish
SO  - J Med Food. 2018 Mar;21(3):225-232. doi: 10.1089/jmf.2017.3941. Epub 2018 Jan 26.