PMID- 29373603
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - N-acetylcysteine alleviates cadmium-induced placental endoplasmic reticulum 
      stress and fetal growth restriction in mice.
PG  - e0191667
LID - 10.1371/journal.pone.0191667 [doi]
LID - e0191667
AB  - Cadmium (Cd) is a developmental toxicant that induces fetal growth restriction 
      (FGR). Placental endoplasmic reticulum (ER) stress is associated with FGR. This 
      study investigated the effects of N-acetylcysteine (NAC) on Cd-induced placental 
      ER stress and FGR. Pregnant mice were intraperitoneally injected with CdCl2 daily 
      from gestational day (GD)13 to GD17. As expected, Cd reduced fetal weight and 
      crown-rump length. Cd decreased the internal space of blood vessels in the 
      placental labyrinth layer and inhibited placental cell proliferation. Several 
      genes of growth factors, such as Vegf-a, placental growth factor, Igf1 and Igf1r, 
      and several genes of nutrient transport pumps, such as Glut1, Fatp1 and Snat2, 
      were down-regulated in placenta of Cd-treated mice. Moreover, Cd evoked placental 
      ER stress. Of interest, NAC alleviated Cd-induced FGR. Additional experiment 
      showed that NAC inhibited Cd-induced impairment of placental development and 
      placental ER stress. Therefore, NAC may be exploited for prevention of Cd-induced 
      placental insufficiency and FGR.
FAU - Guo, Min-Yin
AU  - Guo MY
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, China.
AD  - Department of Histology and Embryology, Anhui Medical University, Hefei, China.
FAU - Xia, Mi-Zhen
AU  - Xia MZ
AD  - Life Science College, Anhui Medical University, Hefei, China.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, China.
FAU - Xu, De-Xiang
AU  - Xu DX
AUID- ORCID: 0000-0002-5126-4335
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 00BH33GNGH (Cadmium)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Animals
MH  - Cadmium/*toxicity
MH  - Down-Regulation/drug effects
MH  - Endoplasmic Reticulum Stress/*drug effects
MH  - Female
MH  - Fetal Growth Retardation/*prevention & control
MH  - Mice
MH  - Placenta/*drug effects
MH  - Pregnancy
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC5786300
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2018/01/27 06:00
MHDA- 2018/02/27 06:00
PMCR- 2018/01/26
CRDT- 2018/01/27 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2018/01/09 00:00 [accepted]
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2018/01/26 00:00 [pmc-release]
AID - PONE-D-17-35350 [pii]
AID - 10.1371/journal.pone.0191667 [doi]
PST - epublish
SO  - PLoS One. 2018 Jan 26;13(1):e0191667. doi: 10.1371/journal.pone.0191667. 
      eCollection 2018.