PMID- 29373900
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Print)
IS  - 1513-7368 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Jan 27
TI  - Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinomas: A Single 
      Center Study from Iran.
PG  - 111-114
AB  - Introduction: Lung cancer is the fifth leading tumor in Iran, and while its 
      incidence remains relatively low, it has been increasing steadily. Targeted 
      therapies have brought new hope to patients with non small cell lung cancer 
      (NSCLC). The epidermal growth factor receptor (EGFR) gene is the prototype member 
      of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in 
      cell proliferation and differentiation. Studies from Asian countries have 
      revealed a higher frequency of EGFR mutations than in the West. The aim of this 
      study was to measure the frequency and type of EGFR mutations in a group of 
      Iranian patients with lung adenocarcinomas. Methods: Formalin fixed paraffin 
      embedded (FFPE) lung adenocarcinoma tissues from 103 Iranian patients were 
      sequentially tested for EGFR mutations by the polymerase chain reaction (PCR) 
      followed by direct nucleotide sequencing of exons 18, 19, 20, and 21. Patient's 
      demographics and other clinical details were obtained from the medical records of 
      hospitals affiliated to Iran University of Medical Sciences, Tehran, Iran. 
      Statistical analyses were performed with SPSS v.20. Results: EGFR mutations were 
      detected in 25/103 (24.3%) patients. The most frequent was an exon 21 point 
      mutation (L858R) (15 patients; 60%), followed by one in exon 19 (10 patients; 
      40%). The frequency of EGFR mutations in never-smoker patients was significantly 
      higher than in smokers (68% versus 32%; p < 0. 01). Conclusion: EGFR mutation 
      frequency is higher than in the West but lower than in East Asian and almost 
      equal to reported rates for Indian and North African populations. Smoking is 
      negatively associated with EGFR mutations in Iranian lung adenocarcinomas.
CI  - Creative Commons Attribution License
FAU - Basi, Ali
AU  - Basi A
AD  - Hematology and Oncology Department, Firoozgar Hospital, Iran University of 
      Medical Sciences, Tehran, Iran. Email: n_rakhshani@yahoo.com
FAU - Khaledi, Flora
AU  - Khaledi F
FAU - Karbalaie Niya, Mohammad Hadi
AU  - Karbalaie Niya MH
FAU - Rezvani, Hamid
AU  - Rezvani H
FAU - Rakhshani, Nasser
AU  - Rakhshani N
LA  - eng
PT  - Journal Article
DEP - 20180127
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
PMC - PMC5844603
OTO - NOTNLM
OT  - *Lung adenocarcinomas
OT  - *epidermal growth factor receptor
OT  - *mutations
OT  - *receptor tyrosine kinase
EDAT- 2018/01/28 06:00
MHDA- 2018/01/28 06:01
PMCR- 2018/03/01
CRDT- 2018/01/28 06:00
PHST- 2018/01/28 06:00 [pubmed]
PHST- 2018/01/28 06:01 [medline]
PHST- 2018/01/28 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - APJCP-19-111 [pii]
AID - 10.22034/APJCP.2018.19.1.111 [doi]
PST - epublish
SO  - Asian Pac J Cancer Prev. 2018 Jan 27;19(1):111-114. doi: 
      10.22034/APJCP.2018.19.1.111.