PMID- 29374794
OWN - NLM
STAT- MEDLINE
DCOM- 20191219
LR  - 20200225
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 58
IP  - 3
DP  - 2019 Apr
TI  - The interaction between apolipoprotein B insertion/deletion polymorphism and 
      macronutrient intake on lipid profile and serum leptin and ghrelin levels in type 
      2 diabetes mellitus patients.
PG  - 1055-1065
LID - 10.1007/s00394-018-1621-5 [doi]
AB  - PURPOSE: We aimed to study whether macronutrient intake could modify the 
      association between ApoB Ins/Del and lipid profile, and serum leptin and ghrelin 
      in type 2 diabetes mellitus (T2DM) patients. METHODS: In this study, 700 T2DM 
      patients were recruited. Anthropometric, biochemical and molecular data were 
      collected, and Diet was assessed using a food frequency questionnaire. The 
      interactions were tested using ANCOVA. RESULTS: Del-allele carriers with 
      high-MUFA and carbohydrate (>/= 12 and >/= 54% of energy, respectively) had 
      significantly higher TG (P = 0.04) and LDL-C (P = 0.02) compared to Ins/Ins 
      homozygotes, and these were not significant in subjects with low-MUFA and 
      -carbohydrate (< 12 and < 54%, respectively). A significant interaction was 
      observed between ApoB Ins/Del and diet on TG in both unadjusted (P = 0.03) and 
      adjusted models (model 2 and 3, P = 0.04 and P = 0.04, respectively), and on 
      LDL-C only in adjusted models (model 2 and 3, P = 0.03 and P = 0.029, 
      respectively). Besides, Del-allele carriers with protein, SFA, MUFA and n-3PUFA 
      of >/= 14, 9, 12 and 0.6%, respectively, had a significant increase in their serum 
      leptin than Ins/Ins homozygotes (P < 0.05). However, these associations were not 
      significant between the two genetic groups in subjects with low intakes of 
      protein, SFA, MUFA and n-3PUFA. Moreover, Del-allele carriers with low 
      carbohydrate (< 54%) had significantly higher leptin and ghrelin than Ins/Ins 
      homozygotes (P < 0.05), however, in high-carbohydrate group, leptin and ghrelin 
      were not significantly lower. CONCLUSIONS: These findings indicate that the 
      interaction between ApoB Ins/Del and dietary intake of MUFA, SFA, n-3PUFA, 
      carbohydrate and protein could modulate the serum levels of TG, LDL-C, leptin and 
      ghrelin in T2DM patients.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Sotoudeh, Gity
AU  - Sotoudeh G
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Djalali, Mahmoud
AU  - Djalali M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Alvandi, Ehsan
AU  - Alvandi E
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Eshraghian, Mohammadreza
AU  - Eshraghian M
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Javadi, Fatemeh
AU  - Javadi F
AD  - School of Nutritional Sciences and Dietetics, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Doostan, Farideh
AU  - Doostan F
AD  - Department of Nutrition, Faculty of Health, Kerman University of Medical 
      Sciences, Kerman, Iran.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. 
      fkoohdan@tums.ac.ir.
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran. 
      fkoohdan@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20180127
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Apolipoproteins B)
RN  - 0 (Ghrelin)
RN  - 0 (Leptin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apolipoproteins B/*genetics
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/genetics
MH  - Female
MH  - Gene Deletion
MH  - Ghrelin/*blood
MH  - Humans
MH  - Leptin/*blood
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Mutagenesis, Insertional/genetics
MH  - Nutrients/*administration & dosage/blood
MH  - Polymorphism, Genetic/*genetics
OTO - NOTNLM
OT  - ApoB Ins/Del
OT  - Diabetes
OT  - Diet
OT  - Leptin
OT  - Lipid
EDAT- 2018/01/29 06:00
MHDA- 2019/12/20 06:00
CRDT- 2018/01/29 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2018/01/23 00:00 [accepted]
PHST- 2018/01/29 06:00 [pubmed]
PHST- 2019/12/20 06:00 [medline]
PHST- 2018/01/29 06:00 [entrez]
AID - 10.1007/s00394-018-1621-5 [pii]
AID - 10.1007/s00394-018-1621-5 [doi]
PST - ppublish
SO  - Eur J Nutr. 2019 Apr;58(3):1055-1065. doi: 10.1007/s00394-018-1621-5. Epub 2018 
      Jan 27.