PMID- 29375045
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20201021
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 68
IP  - 5
DP  - 2017 Oct
TI  - Increased gene expression of selected vesicular and glial glutamate transporters 
      in the frontal cortex in rats exposed to voluntary wheel running.
PG  - 709-714
AB  - Though positive effects of exercise on mood and well being are well recognised, 
      the central regulatory mechanisms are still not fully understood. The present 
      study was aimed to testing the hypothesis that voluntary wheel running activates 
      the gene expression of glutamate transporters in the brain cortex of rats. The 
      animals were assigned to the control and voluntary wheel running groups. 
      Voluntary wheel running rats had free access to a stainless steel activity wheel 
      for 3 weeks. The daily running distance gradually increased to 6.21 +/- 1.05 km by 
      day 21. Vesicular glutamate transporter 3 (VGLUT3) mRNA levels in the frontal 
      cortex were significantly elevated in the group of running animals compared to 
      the values in sedentary controls, while the expression of other vesicular 
      transporters were unchanged. The concentrations of mRNA coding for glial 
      glutamate transporter 1 (GLT-1), but not glutamate aspartate transporter (GLAST) 
      were increased by running. Voluntary wheel running resulted in an elevation of 
      plasma corticosterone and increased expression of brain derived neurotrophic 
      factor (BDNF) in the frontal cortex. In conclusion, chronic voluntary wheel 
      running results in increased gene expression of VGLUT3 and GLT-1 in the brain 
      cortex without changes in other glutamate transporter subtypes.
FAU - Graban, J
AU  - Graban J
AD  - Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental 
      Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Hlavacova, N
AU  - Hlavacova N
AD  - Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental 
      Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia.
FAU - Jezova, D
AU  - Jezova D
AD  - Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental 
      Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 
      Bratislava, Slovakia. daniela.jezova@savba.s.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Amino Acid Transport System X-AG)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Transporter 2)
RN  - 0 (Slc17a7 protein, rat)
RN  - 0 (Slc17a8 protein, rat)
RN  - 0 (Slc1a2 protein, rat)
RN  - 0 (Vesicular Glutamate Transport Protein 1)
RN  - 0 (Vesicular Glutamate Transport Proteins)
SB  - IM
MH  - Amino Acid Transport System X-AG/biosynthesis/genetics
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics
MH  - Excitatory Amino Acid Transporter 2/*biosynthesis/genetics
MH  - Frontal Lobe/*metabolism
MH  - Gene Expression
MH  - Male
MH  - Physical Conditioning, Animal/methods/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vesicular Glutamate Transport Protein 1/biosynthesis/genetics
MH  - Vesicular Glutamate Transport Proteins/*biosynthesis/genetics
EDAT- 2018/01/30 06:00
MHDA- 2018/08/14 06:00
CRDT- 2018/01/30 06:00
PHST- 2017/08/29 00:00 [received]
PHST- 2017/09/27 00:00 [accepted]
PHST- 2018/01/30 06:00 [entrez]
PHST- 2018/01/30 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2017 Oct;68(5):709-714.